08 August 2017 : Clinical Research
Differentiation Diagnosis of Hypo-Intense T2 Area in Unilateral Peripheral Zone of Prostate Using Magnetic Resonance Spectroscopy (MRS): Prostate Carcinoma versus Prostatitis
Tong-hua ZhangABCDEF, Chun-hong HuAD, Jian-xin ChenB, Zheng-dao XuB, Jun-kang ShenGDOI: 10.12659/MSM.903123
Med Sci Monit 2017; 23:3837-3843
Abstract
BACKGROUND: To determine whether magnetic resonance spectroscopy (MRS) can be used as a reliable denominator for the differentiation of prostatitis and prostate cancer (PCa) in the peripheral zone.
MATERIAL AND METHODS: Forty-three patients with unilateral peripheral zone PCa and 35 patients with unilateral peripheral zone prostatitis were recruited for this study. Magnetic resonance imaging (MRI) and MRS were acquired on a 1.5T MR scanner. The ratios of (Cho+Cr)/Cit of hypo-intense T2 area were calculated. The mean ratios of (Cho+Cr)/Cit in hypo-intense T2 area of PCa and that of prostatitis were compared retrospectively by t-test. The citrate and choline amplitudes in the hypo-intense T2 area were compared with that in the contralateral normal peripheral zone tissue.
RESULTS: The mean ratios of (Cho+Cr)/Cit in the hypo-intense T2 area of PCa was 3.0±2.48, whereas that of prostatitis was 5.2±7.08, without significant statistical difference (p=0.306). A reduction in citrate was seen in both PCa and prostatitis tissue, however, choline was elevated in PCa tissue, whereas on the contrary, choline had no significant change in cases of prostatitis.
CONCLUSIONS: The mean ratios of (Cho+Cr)/Cit had no specificity in differentiation of PCa and prostatitis in the peripheral zone, however, the metabolic pattern showed promise as an adjunct to conventional imaging in differentiating prostatitis from PCa in the peripheral zone.
Keywords: Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Prostatic Neoplasms, Prostatitis
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
15 Apr 2024 : Laboratory Research
The Role of Copper-Induced M2 Macrophage Polarization in Protecting Cartilage Matrix in OsteoarthritisMed Sci Monit In Press; DOI: 10.12659/MSM.943738
07 Mar 2024 : Clinical Research
Knowledge of and Attitudes Toward Clinical Trials: A Questionnaire-Based Study of 179 Male Third- and Fourt...Med Sci Monit In Press; DOI: 10.12659/MSM.943468
08 Mar 2024 : Animal Research
Modification of Experimental Model of Necrotizing Enterocolitis (NEC) in Rat Pups by Single Exposure to Hyp...Med Sci Monit In Press; DOI: 10.12659/MSM.943443
18 Apr 2024 : Clinical Research
Comparative Analysis of Open and Closed Sphincterotomy for the Treatment of Chronic Anal Fissure: Safety an...Med Sci Monit In Press; DOI: 10.12659/MSM.944127
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952