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12 May 2017 : Meta-Analysis  

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

Alexander Weymann1DE*, Sadeq Ali-Hasan-Al-Saegh2BCDE, Anton Sabashnikov34DE, Aron-Frederik Popov35E, Seyed Jalil Mirhosseini6AD, Tong Liu7F, Mohammadreza Lotfaliani6F, Michel Pompeu Barros de Oliveira Sá89D, William L. L. Baker10B, Senol Yavuz11B, Mohamed Zeriouh34B, Jae-Sik Jang12B, Hamidreza Dehghan13C, Lei Meng7A, Luca Testa14D, Fabrizio D'Ascenzo15EF, Umberto Benedetto16AC, Gary Tse17CD, Luis Nombela-Franco18CF, Pascal M. Dohmen119EG, Abhishek J. Deshmukh20AF, Cecilia Linde21E, Giuseppe Biondi-Zoccai2223AC, Gregg W. Stone24DE, Hugh Calkins25ADE, Integrated Meta-Analysis of Cardiac Surgery and Cardiology-Group [IMCSC-Group]

DOI: 10.12659/MSMBR.903320

Med Sci Monit Basic Res 2017; 23:179-222


BACKGROUND: Atrial fibrillation (AF) is one of the most critical and frequent arrhythmias precipitating morbidities and mortalities. The complete blood count (CBC) test is an important blood test in clinical practice and is routinely used in the workup of cardiovascular diseases. This systematic review with meta-analysis aimed to determine the strength of evidence for evaluating the association of hematological parameters in the CBC test with new-onset and recurrent AF.

MATERIAL AND METHODS: We conducted a meta-analysis of observational studies evaluating hematologic parameters in patients with new-onset AF and recurrent AF. A comprehensive subgroup analysis was performed to explore potential sources of heterogeneity.

RESULTS: The literature search of all major databases retrieved 2150 studies. After screening, 70 studies were analyzed in the meta-analysis on new-onset AF and 23 studies on recurrent AF. Pooled analysis on new-onset AF showed platelet count (PC) (weighted mean difference (WMD)=WMD of –26.39×10^9/L and p<0.001), mean platelet volume (MPV) (WMD=0.42 FL and p<0.001), white blood cell (WBC) (WMD=–0.005×10^9/L and p=0.83), neutrophil to lymphocyte ratio (NLR) (WMD=0.89 and p<0.001), and red blood cell distribution width (RDW) (WMD=0.61% and p<0.001) as associated factors. Pooled analysis on recurrent AF revealed PC (WMD=–2.71×109/L and p=0.59), WBC (WMD=0.20×10^9/L (95% CI: 0.08 to 0.32; p=0.002), NLR (WMD=0.37 and p<0.001), and RDW (WMD=0.28% and p<0.001).

CONCLUSIONS: Hematological parameters have significant ability to predict occurrence and recurrence of AF. Therefore, emphasizing the potential predictive role of hematological parameters for new-onset and recurrent AF, we recommend adding the CBC test to the diagnostic modalities of AF in clinical practice.

Keywords: Atrial Fibrillation, Blood Platelets, Diagnosis, meta-analysis


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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416