Fifteen-Year Analysis of Deceased Kidney Donation: A Single Transplant Center Experience in a Region of Northern Italy
Vania Cuna, Giorgia Comai, Maria Cappuccilli, Olga Baraldi, Irene Capelli, Matteo De Liberali, Lorenzo Gasperoni, Diletta Conte, Matteo Ravaioli, Antonio D. Pinna, Gaetano La Manna
Department of Experimental, Diagnostic, and Specialty Medicine (DIMES) – Nephrology, Dialysis, and Transplantation Unit, University of Bologna, Bologna, Italy
Med Sci Monit 2017; 23:4482-4489
The rising number of patients on waiting lists for kidney transplant and the shortage of available organs has intensified efforts to increase the number of potential donors.
MATERIAL AND METHODS: This study investigated changes in clinical parameters among potential deceased donors in the 15-year period between 1999 and 2013 and their impact on transplantation procedure and outcomes. A total of 1634 potential deceased donors were examined and divided into 2 groups: 707 of them identified from 1999 to 2005 (Group A), and 927 from 2006 to 2013 (Group B).
RESULTS: The comparison between the potential donors in Group A vs. Group B revealed an increase over time in donor age (54.6±17.2 vs. 58.8±16.3, p<0.001), a reduction in the percentage of standard donors (52.3% vs. 39.8%, p<0.001), a broader utilization of organs from expanded criteria donors, and a greater number of comorbidities, particularly cardiovascular disease and dyslipidemia. However, renal function parameters and the bioptic scores did not change significantly over the years.
CONCLUSIONS: These results suggest the usefulness of strategies to increase the number of potential donors suitable for organ donation, especially among elderly and marginal donors.
Keywords: Kidney Failure, Chronic, Kidney Transplantation, Tissue and Organ Procurement