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Efficacy and Safety of Chemotherapy Combined with Stereotactic Radiotherapy in the Treatment of Nasopharyngeal Carcinoma

Guo-Ping Shan, Bing-Bing Wang, Peng Zheng, Feng-Lei Du, Yi-Wei Yang

Department of Radiation Oncology, Zhejiang Cancer Hospital, and Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, Zhejiang, China (mainland)

Med Sci Monit 2017; 23:5630-5636

DOI: 10.12659/MSM.903903

Available online:

Published: 2017-11-26

BACKGROUND: The aim of this study was to investigate the efficacy and safety of chemotherapy (CT) combined with stereotactic radiotherapy (SRT) in the treatment of nasopharyngeal carcinoma (NPC).
MATERIAL AND METHODS: A total of 329 NPC patients without any previous treatment were included in this study between January 2009 and November 2013. These patients were divided into three groups: CT group (n=114), SRT group (n=109), and CT + SRT group (n=106). Contrast-enhanced nasopharyngeal computed tomography (CT)/magnetic resonance (MR) scan was performed on the third month after treatment. Short-term efficacy was evaluated according to the Response Evaluation Criteria in Solid Tumors (RECIST). Toxicity was graded according to the Acute Radiation Morbidity Scoring Criteria (RTOG) and the World Health Organization (WHO) toxicity grading scale. Overall survival (OS), progression free survival (PFS), and incidence rate of acute toxicity (grade ≥3) were calculated after a 24 month follow-up.
RESULTS: Total response rate of all patients was 85.41%. Compared with the CT group and the SRT group, the CT + SRT group showed a substantially improved efficacy in NPC treatment. The incidence rate of the acute toxicity in the CT + SRT group was slightly higher than in the CT group and the SRT group, but the difference was not statistically significant. No treatment-related deaths were observed. The CT + SRT group had the highest two-year OS and PFS, followed by the CT group and the SRT group.
CONCLUSIONS: It was shown that NPC patients treated with CT + SRT had better short- and long-term efficacy than those treated with CT or SRT alone.

Keywords: Antineoplastic Agents, Nasopharyngeal Neoplasms, Prognosis, Radiosurgery, Toxicity Tests, Acute