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Association of Immune Factors with Drug-Resistant Tuberculosis: A Case-Control Study

En-Tao Sun, Dan Xia, Ben-He Li, Jun Ma, Yuan-Yuan Dong, Shu-Shu Ding, Bai-Feng Chen, Yu-Feng Wen

School of Public Health, Wannan Medical College, Wuhu, Anhui, China (mainland)

Med Sci Monit 2017; 23:5330-5336

DOI: 10.12659/MSM.904309

Available online:

Published: 2017-11-09

BACKGROUND: Presently, studies of factors associated with drug-resistant tuberculosis (TB) focus on patients’ socio-demographic characteristics and living habits, to the exclusion of biochemical indicators, especially immune factors. This study was carried out to determine whether immune factors are associated with drug-resistant TB.
MATERIAL AND METHODS: A total of 227 drug-resistant pulmonary TB patients and 225 drug-susceptible pulmonary TB patients were enrolled in this study. Information on socio-demographic characteristics and biochemical indicators were obtained through their clinical records. Non-conditional logistic regression was used to analyze the association of these indicators with drug-resistant TB.
RESULTS: There were significant differences in re-treatment, marital status, alanine aminotransferase (ALT), blood uric acid (BUA), carcino-embryonic antigen (CEA), T-spot, and CD3 and CD4 counts between the 2 groups. In multivariable analysis, re-treatment [Odds Ratio (OR)=5.290, 95% Confidence Interval [CI]=2.652–10.551); CD3 (OR=1.034, 95% CI=1.001–1.068); CD4 (OR=1.035, 95% CI =1.001–1.070) and IgM (OR=1.845, 95% CI=1.153–2.952) were associated with drug-resistant TB.
CONCLUSIONS: These results suggest the need for greater attention to re-treatment cases and immune function when treating drug-resistant TB.

Keywords: Drug Resistance, Bacterial, Immunity, Cellular, Retreatment, Tuberculosis, Pulmonary