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MicroRNA-588 is downregulated and may have prognostic and functional roles in human breast cancer

Miao Yu, Xin Zhang, Hui Li, Purong Zhang, Wei Dong

Department of Breast Surgery, Sichuan Cancer Hospital, Chengdu, Sichuan, China (mainland)

Med Sci Monit 2017; 23:5690-5696

DOI: 10.12659/MSM.905126

Available online:

Published: 2017-11-30

BACKGROUND: We explored the expression pattern, prognostic potential, and functional role of microRNA-588 (miR-588) in human breast cancer (BC).
MATERIAL AND METHODS: The expression pattern of miR-588 was assessed by qPCR in BC cell lines and human BC carcinomas. The correlations between miR-588 and BC patients’ clinicopathological characteristics, as well as BC patients’ overall survival, were statistically assessed. In in vitro culture, MCF-7 and MDA-MB-231 cells were infected with lentivirus to overexpress endogenous miR-588. The subsequent effects of miR-588 upregulation on BC cell proliferation and cisplatin chemosensitivity were examined.
RESULTS: miR-588 was found to be significantly downregulated in both BC cell lines and carcinoma tissues of BC patients. Low expression of miR-588 was closely correlated with BC patients’ poor prognosis of TNM stage, lymph node metastasis, and estrogen receptor status. In addition, patients with low miR-588-expressing carcinomas had much shorter overall survival. In MCF-7 and MDA-MB-231 cells, lentiviral infection induced significant miR-588 upregulation, and miR-588 upregulation had an anti-tumor effect in BC cells by significantly inhibiting cancer proliferation and increasing cisplatin chemosensitivity.
CONCLUSIONS: miR-588 is downregulated in BC and its aberrant expression is closely associated with patients’ poor prognosis and overall survival, thus suggesting a biomarker role. miR-588 also has anti-tumor function in BC, making it a potential therapeutic target for BC treatment.

Keywords: Carcinoma, Acinar Cell, Triple Negative Breast Neoplasms, Tumor Markers, Biological