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04 February 2018 : Animal Research  

The Expression of Calcium Sensing Receptor in Normal and Diabetic Rat Eyes

Ping Jiang1BCDEF*, Rong Huang1ABCDE, Nan Ma1B, Fagang Jiang1AFG

DOI: 10.12659/MSM.905657

Med Sci Monit 2018; 24: ANS706-710

Abstract

BACKGROUND: Calcium sensing receptor (CaSR) is widely expressed in many tissues of the body, but it is rarely reported to be expressed in the eyes. This research explored the expression and distribution of CaSR in eye tissues of normal and diabetic rats.

MATERIAL AND METHODS: Thirty male Sprague Dawley (SD) rats were randomly divided into a diabetic and a normal group. Diabetes mellitus (DM) models were successfully established by intraperitoneal injection of streptozotocin. The expression and distribution of CaSR in the rat eyeballs were detected by immunohistochemistry. Quantitative RT-PCR and western blotting were used to detect the presence of CaSR in normal and diabetic rats.

RESULTS: CaSR was detected in the cornea, lens epithelium, and retina. CaSR was expressed the most in the cornea, followed by the lens epithelium, and the retina (p<0.05). The expression of CaSR was decreased in the eye tissue of diabetic rats (p<0.05).

CONCLUSIONS: In this study, CaSR was detected in rat cornea, lens, and retina. It was significantly decreased in the eyes of diabetic rats. This indicated that the downregulated expression of CaSR was associated with diabetic oculopathy.

Keywords: Cornea, Diabetic Retinopathy, Lens Diseases, Receptors, Calcium-Sensing, Retina

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416