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09 June 2018 : Clinical Research  

Association Between Blood Lipid Profiles and Atrial Fibrillation: A Case-Control Study

Zhi-Zhao Li12AB*, Xin Du1A, Xue-yuan Guo1A, Ri-bo Tang1A, Chao Jiang1A, Nian Liu1A, San-shuai Chang1A, Rong-hui Yu1A, De-yong Long1A, Rong Bai1A, Cai-hua Sang1A, Song-nan Li1A, Jian-zeng Dong1A, Chang-sheng Ma1A

DOI: 10.12659/MSM.907580

Med Sci Monit 2018; 24: CLR3903-3908

Abstract

BACKGROUND: Dyslipidemia is the most frequent comorbidity in patients with cardiovascular disease. However, studies examining the relationship between blood lipid profiles and AF have produced inconsistent results.

MATERIAL AND METHODS: A total of 651 patients were enrolled into 3 groups: Healthy controls (n=64), Paroxysmal AF (PAF; n=270), and Continuous AF (CAF; n=317). All enrolled patients underwent routine baseline 12-lead electrocardiography (ECG) and 24-h dynamic ECG along with blood testing, which included the following: complete metabolic panel, hepatic function, renal function, circulating thyroxine, fasting high-density lipoprotein cholesterol (HDL -C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC).

RESULTS: Patients with AF had significantly higher levels of triglycerides (TG), lower levels of LDL-C-c, and lower levels of HDL-C (p<0.05). TC (OR 0.979, p<0.9247) and TG (OR 0.945, p<0.6496) were negatively and linearly associated with PAF, while TG (OR 0.807, p=0.2042), LDL-C (OR 0.334, p=0.0036), and HDL-C (OR 0.136, p=0.0002) were negatively and linearly associated with CAF.

CONCLUSIONS: Compared to healthy controls, patients with AF had lower blood lipid levels, especially LDL-c and HDL-c levels. Hypolipoproteinemia may increase patient susceptibility to developing AF.

Keywords: Atrial Fibrillation, Cholesterol, LDL, Triglycerides

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416