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Factors Affecting Liver Regeneration in Living Donors After Hepatectomy

Cem Ibis, Yavor Asenov, Melih Akin, Ibrahim F. Azamat, Nukhet Sivrikoz, Basak Gurtekin

Department of General Surgery, Division of HPB Surgery and Liver Transplantation, Medical Faculty, Istanbul University, Istanbul, Turkey

Med Sci Monit 2017; 23:5986-5993

DOI: 10.12659/MSM.908136

Available online:

Published: 2017-12-18


BACKGROUND: The safety of living liver donors is the paramount priority of liver transplantation surgeons. The liver has an effective regeneration capacity. The regeneration rate of the liver remnant in living liver donors provides much information useful in liver surgery. The outcome of the remnant liver after hepatectomy can be affected by many different perioperative factors.
MATERIAL AND METHODS: A total of 46 patients were enrolled in the study. Retrospective clinical data, including preoperative and postoperative early and late computed tomography liver volumetry measurements, estimated resection volumes, resected liver weights, and postoperative laboratory values, were statistically evaluated according to the liver resection type.
RESULTS: No significant difference was detected in age, sex, calculated and computed tomography estimated total liver volume, intraoperative Hb decrease, postoperative complications, or postoperative portal vein flow rate. Postoperative liver enlargement rates were significant higher in the right hemihepatectomy (RHH) group than in the left lateral sectionectomy (LLS) group. The size of the liver remnant or graft has a major effect on regeneration rate. Postoperative biliary leakage did not have any significant effect on liver regeneration. No post-hepatectomy liver failure was detected among the liver donors.
CONCLUSIONS: Liver hypertrophy depends on the extent of liver resection. The cause of volume decrease in the LLS group after hepatectomy in our series appears to be the gradual atrophy of liver segment 4. RHH and LLS surgeries differ from each other in terms of resected liver volume, as well as inflammatory activity, and the latter appears to affect liver regeneration.

Keywords: Liver Regeneration, Liver Transplantation, Living Donors, Magnetic Resonance Imaging, Organ Size, Spiral Cone-Beam Computed Tomography



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