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02 September 2018 : Clinical Research  

Treatment Outcomes and Prognostic Factors of Adult Sinonasal Sarcomas: A Single-Institution Case Series

Jianming Ding12BE, Cuihong Wang3CD, Jun Xiang4BE, Chunying Shen1EF, Chaosu Hu1AF, Tingting Xu1CD, Xueguan Lu1AF*

DOI: 10.12659/MSM.909116

Med Sci Monit 2018; 24: CLR6113-6118

Abstract

BACKGROUND: The purpose of this study was to investigate the treatment outcomes and evaluate the prognostic factors of adult sinonasal sarcomas.

MATERIAL AND METHODS: A retrospective review was performed on consecutive patients with adult sinonasal sarcomas treated in our institution from 2005 to 2016. The Kaplan-Meier method was used to evaluate local recurrence-free survival (LRFS), distant metastases-free survival (DMFS), and overall survival (OS). Univariate and multivariate analyses using Cox proportional hazard models were performed to determine the prognostic factors associated with survival outcomes.

RESULTS: A total of 49 patients were followed up for 6–122 months, with a median time of 36 months. The 5-year LRFS, DMFS, and OS rates of all patients were 68.3%, 62.8%, and 43.2%, respectively. The results of univariate analysis revealed that patients with an advanced stage of primary tumor and those who received incomplete surgical resection had worse LRFS (p=0.013; p=0.026). Patients with the histological type rhabdomyosarcoma (RMS) and existing regional lymph node metastasis had worse DMFS (p=0.000; p=0.001). The histological type RMS, advanced stage of primary tumor, existing regional lymph node metastasis, and receiving incomplete surgical resection had an unfavorable effect on OS (p=0.001; p=0.002; p=0.008; p=0.011). The results of multivariate analysis showed that histological type and degree of surgical resection were the independent prognostic factors for OS.

CONCLUSIONS: Our results suggest that the histological type RMS and receiving incomplete surgical resection are independent prognostic factors for worse OS.

Keywords: Prognosis, Rhabdomyosarcoma, Sarcoma

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416