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03 December 2018 : Review article  

Treatment of Osteoporosis, with a Focus on 2 Monoclonal Antibodies

Biao Chang1ABCDEF, Qi Quan2BD, Yunqi Li1E, Haixia Qiu1A, Jiang Peng2A, Ying Gu1AG*

DOI: 10.12659/MSM.912309

Med Sci Monit 2018; 24: REV8758-8766

Abstract

ABSTRACT: Osteoporosis is a common skeletal disease characterized by bone loss and subsequent increased risk of fragility fractures. Recent advances in our mechanistic understanding of molecular communications among osteoblasts, osteoclasts, and osteocytes give insight into the important roles of the canonical Wnt/β-catenin pathway and the RANK/RANKL/OPG pathway in the process of bone remodeling. Due to the translation of the canonical Wnt/β-catenin pathway and the RANK/RANKL/OPG pathway in the regulation of osteoblasts and osteoclasts, new targets have been studied in recent years, such as sclerostin and receptor activator of NF-κB ligand (RANKL). In this review, we first introduce the signaling pathways involved in interactions among osteoblasts, osteoclasts, and osteocytes. Next, we describe clinical trials of denosumab and romosozumab, which are monoclonal antibodies that target RANKL and sclerostin, respectively. We analyze the efficacy of these drugs and provide a profile for the management of osteoporosis.

Keywords: Osteoporosis, therapeutic uses, Wnt Signaling Pathway

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416