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20 April 2019 : Meta-Analysis  

The Clinical Effectiveness of Calcium Hydroxide in Root Canal Disinfection of Primary Teeth: A Meta-Analysis

Liying Jia1ABCDEF*, Xiaolin Zhang2ABCDEF, Hong Shi1ABCDEF, Ting Li3F, Bingjian Lv1F, Meng Xie1F

DOI: 10.12659/MSM.913256

Med Sci Monit 2019; 25:2908-2916

Abstract

BACKGROUND: The aim of this research was to systematically analyze the effectiveness of calcium hydroxide compared to formocresol (FC) and camphor phenol (CP) in root canal disinfection of primary teeth.

MATERIAL AND METHODS: The meta-analysis was based on the participants, interventions, control, outcome (PICO) study design principle and 16 randomized-controlled clinical trials published from January 2000 to August 2018. The data heterogeneity of each study was assessed by the Q-test. The odds ratio and 95% confidence interval (CI) were calculated based on the heterogeneity results by Revman software.

RESULTS: Sixteen randomized-controlled clinical trials of 3047 primary teeth were included in this meta-analysis. There were significant differences of clinical effectiveness between calcium hydroxide and FC in root canal disinfection of primary teeth (OR=3.37; 95% CI range: 2.54–4.48, P<0.01) and endodontic inter-appointment emergencies (EIAE) after disinfection for 7 days (OR=0.26; 95% CI range: 0.16–0.42, P<0.01). However, there was no statistical difference of EIAE, after disinfection of primary teeth for 48 hours, between calcium hydroxide and FC (OR=0.62; 95% CI range: 0.34–1.11, P=0.11). There were significant differences of clinical effectiveness between the calcium hydroxide and CP in root canal disinfection of primary teeth (OR=5.50; 95% CI range: 3.36–8.98, P<0.01).

CONCLUSIONS: This meta-analysis indicated that the effectiveness of calcium hydroxide as root canal disinfectant in primary teeth was more effective than that of FC and CP.

Keywords: Calcium Hydroxide, meta-analysis, Root Canal Therapy, Tooth, Deciduous, Camphor, Dental Disinfectants, Dental Pulp Cavity, Drug Combinations, Formocresols, Phenols, Randomized Controlled Trials as Topic, Treatment Outcome

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416