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22 March 2019 : Clinical Research  

The Expression and Clinical Significance of Spleen Tyrosine Kinase in Patients with Coronary Heart Disease

Ke Liang12ABCDEF, Ning Ma2BCF, Shiguo Luo3BD, Wentang Niu2BD, Yong Wang2AF, Peili Bu4ADFG*

DOI: 10.12659/MSM.913543

Med Sci Monit 2019; 25:2112-2121

Abstract

BACKGROUND: Our research was designed to investigate the relationship of spleen tyrosine kinase (Syk) and inflammatory factors with coronary heart disease (CHD) and the risk factors of CHD.

MATERIAL AND METHODS: In our study, 226 patients were enrolled, from October 2017 to March 2018. Clinical and biochemical data were collected. We collected samples of peripheral blood monocytes (PBMs) from the enrolled patients. The patients were divided in 4 groups: patients without coronary artery disease (control group), patients with stable angina pectoris (SAP group), patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS group), and patients with ST-segment elevation acute myocardial infarction group (STEMI group). We detect the protein levels of Syk and inflammatory factors expression by western blot.

RESULTS: Our results found the protein levels of Syk and inflammatory factors expression in the NSTE-ACS and STEMI groups were higher than those in the SAP and control groups. The protein levels of Syk and inflammatory factors expression in the SAP group were higher than those in the control group. Moreover, there were many risk factors significantly associated with Syk. Besides that, these risk factors were also independent risk factors of CHD.

CONCLUSIONS: Our results found that the level of Syk was associated with the severity of CHD. From our study, we found that higher levels of Syk and inflammatory factors protein were associated with worse results of the CHD. For the first time, Syk was reported to be a promising therapeutic factor for CHD patients.

Keywords: Coronary Disease, Risk Factors, Adult, Aged, Case-Control Studies, Middle Aged, Monocytes, percutaneous coronary intervention, Syk Kinase, transcriptome

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416