Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

03 March 2019 : Meta-Analysis  

Interleukin-8 Gene –251 A/T (rs4073) Polymorphism and Coronary Artery Disease Risk: A Meta-Analysis

Shunrong Zhang1ABCE, Yue Gao1BCD, Jinyu Huang2BCDEFG*

DOI: 10.12659/MSM.913591

Med Sci Monit 2019; 25:1645-1655


BACKGROUND: Inflammation plays an important role in the pathogenesis of coronary artery disease (CAD). Studies have reported that inflammatory cytokine interleukin-8 (IL-8) gene –251 A/T (rs4073) polymorphism is correlated with CAD susceptibility, but the result remains controversial. The objective of this study was to clarify the association between IL-8 gene –251 A/T polymorphism and CAD risk.

MATERIAL AND METHODS: A meta-analysis included 8244 patients from 9 individual studies with 10 populations was conducted. Heterogeneity test was conducted, and pooled odds ratio (OR) with 95% confidence interval (CI) was calculated used fixed-effect or random-effects model accordingly. Publication bias was evaluated with the Begg’s funnel plot and Egger’s test. Sensitivity analysis was also conducted.

RESULTS: A significant association between IL-8 gene –251 A/T polymorphism and CAD risk was found in the dominant model (OR 1.42, 95% CI 1.16–1.76, P<0.001), recessive model (OR 1.30, 95% CI 1.12–1.52, P<0.001), allelic model (OR 1.28, 95% CI 1.12–1.47, P<0.001), homozygote model (OR 1.59, 95% CI 1.21–2.08, P<0.001), and heterozygote model (OR 1.35, 95% CI 1.11–1.64, P=0.002). Subgroup analysis by ethnicity found significant associations in the Chinese population in the dominant model(OR 1.43, 95% CI 1.26–1.61, P<0.001), recessive model (OR 1.39, 95% CI 1.21–1.59, P<0.001), allelic model (OR 1.31, 95% CI 1.21–1.42, P<0.001), homozygote model (OR 1.66, 95% CI 1.41–1.95, P<0.001), and heterozygote model (OR 1.34, 95% CI 1.18–1.52, P<0.001), but no significant association was found in the Caucasian population. No significant publication bias was found.

CONCLUSIONS: The IL-8 gene –251 A/T polymorphism was significantly associated with CAD risk in the Chinese population but not in the Caucasian population, –251 A allele carrier had an increased risk of CAD in the Chinese population.

Keywords: Coronary Artery Disease, genetic variation, Interleukin-8, meta-analysis, Alleles, Asians, China, Gene Frequency, Genetic Predisposition to Disease, Genotype, Odds Ratio, Polymorphism, Single Nucleotide, Whites


Most Viewed Current Articles

13 Apr 2020 : Original article  

Outcome of 24 Weeks of Combined Schroth and Pilates Exercises on Cobb Angle, Angle of Trunk Rotation, Chest...

DOI :10.12659/MSMBR.920449

Med Sci Monit Basic Res 2020; 26:e920449

11 May 2020 : Original article  

Analysis of Psychological and Sleep Status and Exercise Rehabilitation of Front-Line Clinical Staff in the ...

DOI :10.12659/MSMBR.924085

Med Sci Monit Basic Res 2020; 26:e924085

05 Jan 2021 : Review article  

A Southeast Asian Perspective on the COVID-19 Pandemic: Hemoglobin E (HbE)-Trait Confers Resistance Against...

DOI :10.12659/MSMBR.929207

Med Sci Monit Basic Res 2021; 27:e929207

10 Aug 2020 : Clinical Research  

Effects of Cognitive Task Training on Dynamic Balance and Gait of Patients with Stroke: A Preliminary Rando...

DOI :10.12659/MSMBR.925264

Med Sci Monit Basic Res 2020; 26:e925264

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416