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07 June 2019 : Meta-Analysis  

Efficacy and Safety of “On-Demand” Dapoxetine in Treatment of Patients with Premature Ejaculation: A Meta-Analysis

Yuefeng Du12ABCDE, Yumei Jiang12ABCDE, Jing Zhang1ABCDEFG, Ge Tian1ABCD, Na Zhang1ABCEF, Dapeng Wu1ABCDEFG, Xiaojing Bai12ABCDEFG*

DOI: 10.12659/MSM.913606

Med Sci Monit 2019; 25:4225-4232


BACKGROUND: The aim of this study was to assess the efficacy and safety of “on-demand” dapoxetine in the treatment of premature ejaculation (PE).

MATERIAL AND METHODS: We performed a meta-analysis of intravaginal ejaculatory latency time (IELT), patient-reported global impression of change (PGIC), perceived control over ejaculation (PCOE), and drug-related adverse effects (AEs). We searched Medline, PubMed, Embase, CNKI, Wanfang, and VIP databases up to May 30, 2018 with the following search terms: “dapoxetine” or “SSRIs” and “premature ejaculation” or “sexual dysfunction”.

RESULTS: Our analysis included 11 RCTs (8521 cases and 4338 controls). We found that IELT, PGIC, and PCOE in PE patients with “on-demand” dapoxetine were significantly higher than in the control group, and we observed higher proportions in 60 mg vs. 30 mg dapoxetine. The AEs were mild and tolerable.

CONCLUSIONS: “On-demand” dapoxetine is effective and safe for patients with PE, and a dose of 60 mg may be more effective than 30 mg.

Keywords: meta-analysis, Patients, premature ejaculation, Safety, Adult, Benzylamines, Drug-Related Side Effects and Adverse Reactions, Ejaculation, Middle Aged, Naphthalenes, Serotonin Uptake Inhibitors, Treatment Outcome


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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416