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28 March 2019 : Laboratory Research  

VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

Xian-Jie Wu1ABCDEFG, Jing Jing1ABCDEFG, Zhong-Fa Lu1ADG*, Min Zheng1ABE

DOI: 10.12659/MSMBR.914570

Med Sci Monit Basic Res 2019; 25:107-112

Abstract

BACKGROUND: Recent research reports that VEGFR-2 is expressed in the whole hair follicle, sebaceous glands, eccrine sweat glands, and epidermis. However, phosphorylated VEGFR-2 was not found, and it could not be ascertained whether the activated form of VEGFR-2 actually participates in the biological control of epidermal appendages. In this study we aimed to determine whether the VEGFR-2 pathway is directly involved in the daily regulation of epidermal appendages biology.

MATERIAL AND METHODS: In this study, we investigated the expression of phosphorylation of VEGFR-2 by immunohistochemical analysis in the epidermis and epidermal appendages in normal human scalp skin.

RESULTS: Immunohistochemical analysis revealed phosphorylation of VEGFR-2 in a whole hair follicle, mainly in the infundibulum basal layer, hair cortex, and medulla in the isthmus, and matrix in the hair bulb. Phosphorylated VEGFR-2 also was found in the sebaceous glands, eccrine sweat glands, and epidermis.

CONCLUSIONS: Therefore, we suggest that VEGFR-2 activation is involved in routine regulation of human epidermal appendages.

Keywords: Antibodies, Phospho-Specific, Hair Follicle, Scalp, Vascular Endothelial Growth Factor Receptor-2, Adult, Eccrine Glands, Epidermis, Immunohistochemistry, Phosphorylation, Sebaceous Glands, young adult

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416