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VEGFR-2 Is in a State of Activation in Hair Follicles, Sebaceous Glands, Eccrine Sweat Glands, and Epidermis from Human Scalp: An In Situ Immunohistochemistry Study of Phosphorylated VEGFR-2

Xian-Jie Wu, Jing Jing, Zhong-Fa Lu, Min Zheng

Department of Dermatology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland)

Med Sci Monit Basic Res 2019; 25:107-112

DOI: 10.12659/MSMBR.914570

Available online: 2019-03-28

Published: 2019-03-28


BACKGROUND: Recent research reports that VEGFR-2 is expressed in the whole hair follicle, sebaceous glands, eccrine sweat glands, and epidermis. However, phosphorylated VEGFR-2 was not found, and it could not be ascertained whether the activated form of VEGFR-2 actually participates in the biological control of epidermal appendages. In this study we aimed to determine whether the VEGFR-2 pathway is directly involved in the daily regulation of epidermal appendages biology.
MATERIAL AND METHODS: In this study, we investigated the expression of phosphorylation of VEGFR-2 by immunohistochemical analysis in the epidermis and epidermal appendages in normal human scalp skin.
RESULTS: Immunohistochemical analysis revealed phosphorylation of VEGFR-2 in a whole hair follicle, mainly in the infundibulum basal layer, hair cortex, and medulla in the isthmus, and matrix in the hair bulb. Phosphorylated VEGFR-2 also was found in the sebaceous glands, eccrine sweat glands, and epidermis.
CONCLUSIONS: Therefore, we suggest that VEGFR-2 activation is involved in routine regulation of human epidermal appendages.

Keywords: Antibodies, Phospho-Specific, Hair Follicle, Scalp, Vascular Endothelial Growth Factor Receptor-2