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14 March 2019 : Original article  

Chemical Composition and Biological Activities of Lebanese Pentapera Plant

Hany Kallassy1ABDEFG, Hussein Fayyad-Kazan1ACEF, Rawan Makki1BCD, Monya Kaeen1BDE, Amer Sakr2BD, Osama Alyamani2BD, Rim El Dirani1DE, Eva Hamade1AEF, Mohammad Fayyad-Kazan1ABDEF*, Bassam Badran1ADEG

DOI: 10.12659/MSMBR.914741

Med Sci Monit Basic Res 2019; 25:88-99

Abstract

BACKGROUND: Due to their chemical constituents and biological properties, plants have long been used to control life-threatening diseases. The flora of Lebanon includes many plants that have already been demonstrated to have medicinal value, and other species, such as Pentapera sicula libanotica, that are yet to be characterized. The present study characterized the chemical composition, anti-oxidant, anti-inflammatory, and anti-proliferative potential of aqueous, ethanol, and methanol extracts derived from the leaves of the Lebanese Pentapera plant.

MATERIAL AND METHODS: High-performance liquid chromatography (HPLC) was used to determine the chemical composition. Gas chromatography (GC) coupled with mass spectrometry (MS) was applied to determine the content of essential oil. DPPH radical scavenging assay was performed to evaluate the anti-oxidant potential. The anti-inflammatory potential was assessed using quantitative real-time PCR (qRT-PCR) by measuring TNF-α, IL-6, and CCL4 mRNA levels, and we assessed Cox-2 and iNOS proteins levels using Western blot (WB) analysis. MTT assay was carried out to determine the anti-proliferative potential.

RESULTS: We identified, mainly in the alcoholic (methanol and ethanol) extracts, distinct bioactive compounds with pharmacological relevance. In parallel, with their phytochemical content, these 2 extracts showed significant anti-oxidant, anti-inflammatory and anti-proliferative capacities.

CONCLUSIONS: Pentapera sicula libanotica appears to be a promising pharmacological tool.

Keywords: Anti-Inflammatory Agents, Antioxidants, Cell Survival, Chromatography, High Pressure Liquid, Ericaceae, phytochemicals, Phytotherapy, Plant Extracts, Plant Leaves

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416