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25 August 2019 : Review article  

The Roles of Circular RNAs in Osteosarcoma

Yong Zhang1BDEF, Jiale Li1BEF, Yinsheng Wang1CF, Juehua Jing1EF, Jun Li1AG*

DOI: 10.12659/MSM.915559

Med Sci Monit 2019; 25:6378-6382

Abstract

ABSTRACT: Osteosarcoma is a malignant tumor that occurs most commonly in the metaphysis of the long bones in the limbs in children and adolescents. Even with surgery and neoadjuvant chemotherapy, the therapeutic effect has reached a peak with 60–70% survival rates. Therefore, new biological targets or molecular mechanisms that enhance the efficacy of osteosarcoma treatments are needed. Circular RNAs (circRNAs) are useful biomarkers that have recently been recognized clinically and in medical research and have been of interest due to the use of next-generation sequencing and bioinformatics analysis. CircRNAs are involved in many diseases, including cancer. Therefore, this review aims to summarize the roles of circRNA in the diagnosis, progression, and prognosis of osteosarcoma.

Keywords: Osteosarcoma, review, RNA, Ribosomal, Biomarkers, Tumor, Computational Biology, High-Throughput Nucleotide Sequencing, MicroRNAs, Prognosis, RNA, RNA, Circular

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416