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Fibromyalgia and its New Lessons for Neuropsychiatry

Laura Duque, Gregory Fricchione

Department of Psychiatry, Massachusetts General Hospital – Harvard Medical School, Boston, MA, USA

Med Sci Monit Basic Res 2019; 25:169-178

DOI: 10.12659/MSMBR.915962

Available online: 2019-07-05

Published: 2019-07-05


ABSTRACT: Fibromyalgia (FM) is a centralized pain state that until recently has been shrouded in mystery and questionable as a disease entity in the eyes of many physicians, who considered it purely psychogenic. Fibromyalgia is now thought of as a discrete diagnosis with a clustering of symptoms characterized by central nervous system pain amplification along with anergia, memory loss, disturbances of mood, and sleep disruption. The condition is present in approximately 2% to 8% of the population.
We review the link between inflammatory mechanisms and FM from a neuropsychiatric perspective.
Recent studies are pointing to a neuroinflammatory etiology that may open up more effective treatment strategies in the future.
Better conceptualization of FM may also elucidate a neuropsychiatric understanding of how nociception, dysthymia, and suicidality co-develop and feed off one another.

Keywords: Central Nervous System, Fibromyalgia, Neuropsychiatry, Neuroimmunomodulation