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Relationship Between Diabetes Mellitus and Cirrhosis Risk in Chronic Hepatitis B Patients in Wuhan, China

Chu Xu, Juanjuan Chen, Ping-an Zhang

Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland)

Med Sci Monit 2019; 25:8112-8119

DOI: 10.12659/MSM.917000

Available online:

Published: 2019-10-29

BACKGROUND: The objective of our research was to assess the possible link between diabetes mellitus (DM) and liver cirrhosis in chronic hepatitis B (CHB) patients in Wuhan, China.
MATERIAL AND METHODS: Individuals with a diagnosis of both liver cirrhosis and chronic HBV infection (n=257), and CHB-only patients (n=514) were matched 1: 2 by age and sex. Demographic, lifestyle, laboratory, and clinical characteristics were reviewed. Univariate and the multiple logistic regression analysis were conducted to investigate the association between DM and HBV-related liver cirrhosis.
RESULTS: The prevalence of DM was higher among CHB patients with liver cirrhosis than in those without liver cirrhosis (22.2% vs. 12.8%, P=0.001), yielding an adjusted odds ratio (AOR) of 2.317 and a 95% confidence interval (CI) of 1.528-3.513. Among them, 87.7% of liver cirrhosis patients were diagnosed with DM before liver cirrhosis diagnosis, yielding an AOR (95% CI) of 2.386 (1.533-3.714). In comparison to patients with a DM duration of 2-5 years, the AOR (95% CI) for those with a DM duration >5 years was 2.073 (0.701-6.132). In DM treatment, the AOR (95% CI) for those treated with insulin was 4.746 (1.329-16.949).
CONCLUSIONS: DM was associated with cirrhosis risk in CHB patients in Wuhan, China.

Keywords: Diabetes Mellitus, Hepatitis B, Chronic, Liver Cirrhosis, Risk Factors