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10 September 2019 : Original article  

Benefit of Reducing Body Weight Loss with A Nutritional Support Pathway in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

Takashi Aoyama1ABCDEFG*, Kanako Yoshitsugu2B, Masafumi Fukaya2B, Tetsuo Kume3B, Miho Kawashima4B, Kazuko Nakajima5B, Hidekazu Arai6D, Osamu Imataki7D, Terukazu Enami2B, Raine Tatara2B, Takashi Ikeda2B

DOI: 10.12659/MSMBR.917329

Med Sci Monit Basic Res 2019; 25:187-198

Abstract

BACKGROUND: This retrospective, historically controlled investigative study examined the utility of a nutritional support pathway that included nutritional education before the start of conditioning and emphasized oral nutrition in response to nutrition-related adverse events in patients undergoing hematopoietic stem cell transplantation (HSCT).

MATERIAL AND METHODS: Participants were patients undergoing allogeneic HSCT; 46 were in the control group (i.e., did not follow our nutritional pathway) and 36 were in the group that underwent nutritional intervention (enhanced nutrition group). We compared the following parameters between groups from the day before the start of conditioning to the day after completion of parenteral nutrition (PN): percent loss of body weight (%LBW), percent loss of skeletal muscle mass (%LSMM), and estimated basal energy expenditure (EBEE) sufficiency rate. The relationship between each parameter and %LBW was also examined. We also compared nutritional indices, gastrointestinal graft versus host disease (GvHD) grade, oral energy intake, and %LBW between groups.

RESULTS: There was a relationship between %LBW, %LSMM, and EBEE sufficiency rate in both groups. Compared with the control group, the enhanced nutrition group had significantly improved energy intake amount, EBEE sufficiency rate, PN duration, and oral energy intake over time. The enhanced nutrition group also had increased oral energy intake, no difference in gastrointestinal GvHD grade, and improved %LBW compared with the control group.

CONCLUSIONS: Use of our nutritional support pathway in patients undergoing HSCT may be beneficial for %LBW and gastrointestinal GvHD grade, enabling early enhanced nutritional intervention after HSCT.

Keywords: Nutritional Support, Nutrition Assessment, Transplantation, Homologous, Graft vs Host Disease, Adolescent, Adult, Aged, Body Weight, Energy Intake, Energy Metabolism, Hematopoietic Stem Cell Transplantation, Japan, Middle Aged, Parenteral Nutrition, Retrospective Studies, Weight Loss

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416