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Strain Elastography-Targeted Biopsy: Does Prostate Volume Affect Prostate Cancer Detection?

Yi-Cheng Zhu, Jun Shan, Yuan Zhang, Quan Jiang, Yong-Bing Wang, Shu-Hao Deng, Qing-Hua Qu, Qing Li

Department of Ultrasound, Pudong New Area People’s Hospital Affiliated to Shanghai University of Medicine and Health Sciences, Pudong, Shanghai, China (mainland)

Med Sci Monit 2019; 25:8836-8842

DOI: 10.12659/MSM.917344

Available online:

Published: 2019-11-22

BACKGROUND: The present study aimed to assess the correlation between prostate volume and prostate cancer (PCa) detection by strain elastography (SE)-guided targeted biopsy (TB) compared with conventional transrectal ultrasound (TRUS)-guided systematic biopsy (SB).
MATERIAL AND METHODS: This retrospective study enrolled 357 patients suspected to have PCa. All patients received TRUS-guided 10-core SB and SE-guided TB. The sensitivity for PCa detected by SE-guided TB was compared with that by TRUS-guided SB, in combination with prostate biopsy pathology. The correlation between the prostate volume and the detection rate of SE-guided TB was investigated.
RESULTS: PCa was pathologically confirmed in 151 out of 357 patients. The by-patient detection rate of TRUS-guided SB was 72.8% (110/151). Subsequently, a further increase of 6.6% (10/151) in PCa determination was obtained by the SE-guided TB. The sensitivity of SE-guided TB for patients with prostate volume <30 ml, 30-50 ml, 51-80 ml, and >80 ml was 91.7% (44/48), 80.3% (53/66), 70.4% (19/27), and 40.0% (4/10), respectively (p=0.002). For patients with a prostate volume less than 30 ml, SE-guided TB (91.7%) had a higher sensitivity than SB (62.5%) (p<0.007).
CONCLUSIONS: SE-guided TB has a higher detection rate of PCa in comparison with TRUS-guided SB. There was also a negative correlation between prostate volume and SE-guided TB. Therefore, use of SE-guided TB may complement use of conventional SB, especially for patients with smaller prostate volume.

Keywords: Elasticity Imaging Techniques, Image-Guided Biopsy, Prostatic Neoplasms, Ultrasonography