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05 February 2020 : Clinical Research  

Use of a Systematic Pharmacological Methodology to Explore the Mechanism of Shengmai Powder in Treating Diabetic Cardiomyopathy

Shi-ying Zhang1234ABCDE, Kai-lin Yang56ABCDE, Zhi-yong Long78ABCDE, Wei-qing Li134ABCDFG*, Hui-yong Huang2ABCDFG

DOI: 10.12659/MSM.919029

Med Sci Monit 2020; 26:e919029

Abstract

BACKGROUND: Cardiovascular complications, such as diabetic cardiomyopathy (DCM), are the leading cause of death in diabetic patients. Shengmai Powder (SMP) was found to have cardioprotective effects.

MATERIAL AND METHODS: Based on the systematic pharmacological methodology, this research determined the genes of DCM and the known targets of SMP, predicted potential compounds and targets of SMP, constructed networks for DCM and SMP, and performed network analysis.

RESULTS: Five network were constructed: (1) the DCM gene PPI network; (2) the Compound-compound target network of SMP; (3) the SMP-DCM PPI network; (4) the Compound-known target network of SMP; (5) and the SMP known target-DCM PPI network. Several DCM and treatment related targets, clusters, signaling pathways, and biological processes were found.

CONCLUSIONS: SMP is able to regulate glycometabolism-related, lipid metabolism-related, inflammatory response-related, oxidative stress-related signaling pathways, and biological processes and targets, which suggests that SMP may have a therapeutic effect on DCM.

Keywords: Diabetic Cardiomyopathies, herbal medicine, Medicine, Chinese Traditional, Cardiotonic Agents, Cluster Analysis, Drug Combinations, Drugs, Chinese Herbal, Gene Regulatory Networks, Powders

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416