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A Pilot Study of Third-Generation Dual-Source Computed Tomography for the Assessment of Global Dynamic Changes in Left Ventricular Structure and Function in a Porcine Model of Acute Myocardial Infarction

Wenjia Li, Liang Lyu, Weixin Yang, Rongshun Zhang, Gang Wang, Dong Fang, Wei Song, Junkun Yin, Jiangmao Yang, Wei Li, Liling Chen, Tianyou Luo

Chongqing Medical University, Chongqing, China (mainland)

Med Sci Monit 2019; 25:7989-7997

DOI: 10.12659/MSM.919122

Available online:

Published: 2019-10-25

BACKGROUND: First-generation and second-generation dual-source computed tomography (DSCT) are useful for analyzing left ventricle (LV) structure and function. This pilot study aimed to investigate the feasibility and role of third-generation DSCT for the evaluation of dynamic changes in LV structural and functional characteristics in a Diannan small-ear pig model of acute myocardial infarction (AMI).
MATERIAL AND METHODS: The model of AMI was established by balloon occlusion of the distal third of the left anterior descending (LAD) coronary artery in 14 Diannan small-eared pigs. Third-generation DSCT was performed to observe dynamic changes in LV structure and function before and after AMI was induced, with a follow-up period of 30 days.
RESULTS: The mean structural measurements at baseline included interventricular septum thickness (8.50±0.90 mm), LV anterior wall thickness (8.40±1.30 mm), LV posterior wall thickness (7.80±1.20 mm), LV end-diastolic dimension (LVEDD) (45.00±4.90 mm), and LV end-systolic dimension (LVESD) (25.90±4.10 mm). The mean functional measurements at baseline included the LV end-diastolic volume (LVEDV) (74.62±13.54 ml), LV end-systolic volume (LVESV) (23.06±7.46 ml), LV ejection fraction (LVEF) (69.29±6.83%), LV mass (86.35±14.02 g), stroke volume (SV) (51.56±9.77 ml), and cardiac output (CO) (4.22±2.14 l/min). Trends of time-dependent changes were observed for LVESV, LVEF, SV, and CO, but not for LVEDV or LV mass.
CONCLUSIONS: Third-generation DSCT was validated as a tool for assessing dynamic changes in LV global function in a porcine model of AMI.

Keywords: Coronary Artery Disease, multidetector computed tomography, Swine, Ventricular Function, Left