30 January 2020 : Review article
Osteopontin in Bone Metabolism and Bone Diseases
Jinyan SiABCDEF, Chaowei WangBCF, Denghui ZhangEF, Bo WangEF, Yi ZhouAFGDOI: 10.12659/MSM.919159
Med Sci Monit 2020; 26:e919159
Abstract
Osteopontin (OPN), a secreted phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. Studies have shown that OPN plays a role in bone metabolism and homeostasis. OPN not only is an important factor in neuron-mediated and endocrine-regulated bone mass, but also is involved in biological activities such as proliferation, migration, and adhesion of several bone-related cells, including bone marrow mesenchymal stem cells, hematopoietic stem cells, osteoclasts, and osteoblasts. OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as osteoporosis, rheumatoid arthritis, and osteosarcoma. As expected, the functions of OPN in the bone have become a research hotspot. In this article, we try to decipher the mechanism of OPN-regulated bone metabolism and bone diseases.
Keywords: Bone Diseases, Bone Diseases, Metabolic, Osteopontin, Bone Development, Bone and Bones, Calcinosis, Organ Size
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