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The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China

Hua-Wei Liu, Dai-Xu Wei, Da-Wei He, Jiu-Zheng Deng, Jian-Jin Zhu, Kai Xu, Dong Hu, Jing Li, Wen-Hao Hu, Yan Wang, Song-Hua Xiao, Li-Gong Fu

Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China (mainland)

Med Sci Monit 2020; 26:e920956

DOI: 10.12659/MSM.920956

Available online: 2020-07-09

Published: 2020-09-06

BACKGROUND: The study aimed to explore the genetic association of Fc receptor-like 5 (FCRL5) gene variants (rs6427384 and rs6692977) with ankylosing spondylitis risk in Chinese Han population.
MATERIAL AND METHODS: Genotyping for FCRL5 gene variations rs6427384 and rs6692977 was implemented among 130 ankylosing spondylitis cases and 135 healthy persons, through polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. Frequency dissimilarity for 2 polymorphisms was compared between 2 groups using chi-square test. The association strength of FCRL5 gene polymorphism with ankylosing spondylitis risk was estimated by odds ratios with 95% confidence intervals.
RESULTS: The frequencies of rs6427384 CC genotype and C allele were significantly lower in the case group than that in the control group (P<0.05), which suggested that C allele of rs6427384 polymorphism might offer protection against ankylosing spondylitis onset. Whereas only 2 genotypes of rs6692977 were detected in the control group, and no significant association was found with ankylosing spondylitis susceptibility.
CONCLUSIONS: FCRL5 gene polymorphism rs6427384 was correlated to ankylosing spondylitis occurrence among Chinese Han population, while rs6692977 was not.

Keywords: Polymorphism, Genetic, Receptors, Fc, Spondylitis, Ankylosing