Multicenter Clinical Trials Analyzing Efficacy and Safety of Topical Cortex Phellodendri Compound Fluid in Treatment of Diabetic Foot Ulcers
Yali Liu, Youshan Li, Yuqing Du, Tianyi Huang, Chunyan Zhu
Department of Peripheral Vascular Surgery, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China (mainland)
Med Sci Monit 2020; 26:e923424
Available online: 2020-06-19
The aim of this study was to analyze the clinical application of cortex phellodendri compound fluid (CPCF) in the treatment of diabetic foot ulcers.
MATERIAL AND METHODS: From January 2012 to December 2015, a total of 720 cases of diabetic foot ulcers (DFU) were randomly assigned into an experimental group (n=540) that was treated by CPCF and a control group (n=180) that was treated by a Kangfuxin solution (KFS). After 4 weeks of treatment, their ulcer area, serum growth factor, clinical total effective rate, and incidence of adverse events were assessed.
RESULTS: There were 720 patients who completed the trial. The experimental group was superior to the control group in reducing ulcer area, increasing growth factor content, and total effective rate (P<0.05). There was no significant difference in the adverse events rates between the 2 groups.
CONCLUSIONS: CPCF external treatment of diabetic foot ulcer can promote ulcer healing and increase the concentration of growth factors, and it is safe and reliable.
Keywords: Diabetic Foot, lipid metabolism disorders, Medicine, Chinese Traditional