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Use of Enhanced Recovery After Surgery (ERAS) in Laparoscopic Cholecystectomy (LC) Combined with Laparoscopic Common Bile Duct Exploration (LCBDE): A Cohort Study

Nannan Zhang, Gang Wu, Yuanhang Zhou, Zhiwei Liao, Jinxing Guo, Yongjun Liu, Qi Huang, Xiaodong Li

Department of General Surgery, Baoshan Branch of Huashan North Courtyard Affiliated to Fudan University, (Renhe Hospital, Baoshan District, Shanghai), Shanghai, China (mainland)

Med Sci Monit 2020; 26:e924946

DOI: 10.12659/MSM.924946

Chinese Clinical Trial Registry # ChiCTR1900024292

Available online: 2020-07-17

Published: 2020-09-12

BACKGROUND: The have been few reports on use of ERAS in LC combined with LCBDE to promote postoperative recovery of patients. Therefore, the purpose of this cohort study was to explore the use of ERAS in patients who underwent LC combined with LCBDE.
MATERIAL AND METHODS: We collected clinical data of 445 patients who underwent elective laparoscopic cholecystectomy combined with laparoscopic common bile duct exploration from January 2015 to February 2019 in our hospital and divided the patients into an E-LC group and an LC group. The stress response index, postoperative complication rate, and postoperative rehabilitation effect of the 2 groups were compared and analyzed.
RESULTS: The WBC count and CRP levels in the E-LC group were significantly lower than those of the LC group 1 day after surgery (p<0.05). In terms of the postoperative complications, the incidence of nausea, incisional pain, and vomiting in the E-LC group were lower than in the LC group, and the differences were statistically significant (p<0.05). In terms of the postoperative rehabilitation efficacy, flatus time and length of hospital stay after surgery in the E-LC group were significantly shorter than those in the LC group (p<0.05).
CONCLUSIONS: Use of ERAS in the perioperative period in patients who underwent LC combined with LCBDE reduces the stress response and postoperative complications and accelerates postoperative rehabilitation.

Keywords: Cholecystectomy, Laparoscopic, Laparoscopy, Surgical Procedures, Minimally Invasive