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A Comparison of Clinical Characteristics and Outcomes in Elderly and Younger Patients with COVID-19

Jia Song, Weihang Hu, Yihua Yu, Xin Shen, Yueben Wang, Jin Yan, Xianghong Yang, Shijin Gong, Minjia Wang

Intensive Care Unit, Zhejiang Hospital, Hangzhou, Zhejiang, China (mainland)

Med Sci Monit 2020; 26:e925047

DOI: 10.12659/MSM.925047

Available online: 2020-06-01

Published: 2020-07-28

BACKGROUND: The aim of this study was to describe the clinical characteristics and outcomes of patients with coronavirus disease 2019 (COVID-19) and compare these parameters in an elderly group with those in a younger group.
MATERIAL AND METHODS: This retrospective, single-center observational study included 69 hospitalized patients with laboratory-confirmed COVID-19 from a tertiary hospital in Wuhan, China, between January 14, 2020, and February 26, 2020. Epidemiological, demographic, clinical, and laboratory data, as well as treatments, complications, and outcomes were extracted from electronic medical records and compared between elderly patients (aged ≥60 years) and younger patients (aged <60 years). Patients were followed until March 19, 2020.
RESULTS: Elderly patients had more complications than younger patients, including acute respiratory distress syndrome (ARDS; 9/25, 36% vs. 5/44, 11.4%) and cardiac injury (7/25, 28% vs. 1/44, 2.3%), and they were more likely to be admitted to the intensive care unit (6/25, 24% vs. 2/44, 4.5%). As of March 19, 2020, 60/69 (87%) of the patients had been discharged, 6/69 (8.7%) had died, and 3/69 (4.3%) remained in the hospital. Of those who were discharged or died, the median duration of hospitalization was 13.5 days (interquartile range, 10-18 days).
CONCLUSIONS: Elderly patients with confirmed COVID-19 were more likely to develop ARDS and cardiac injury than younger patients and were more likely to be admitted to the intensive care unit. In addition to routine monitoring and respiratory support, cardiac monitoring and supportive care should be a focus in elderly patients with COVID-19.

Keywords: Coronavirus Infections, COVID-19, Pneumonia, Viral