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Abnormal Fractional Amplitude of Low-Frequency Fluctuation Changes in Patients with Monocular Blindness: A Functional Magnetic Resonance Imaging (MRI) Study

Jian-Wen Fang, Ya-Jie Yu, Li-Ying Tang, Si-Yi Chen, Meng-Yao Zhang, Tie Sun, Shi-Nan Wu, Kang Yu, Biao Li, Yi Shao

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China (mainland)

Med Sci Monit 2020; 26:e926224

DOI: 10.12659/MSM.926224

Available online: 2020-08-03

Published: 2020-08-10

BACKGROUND: We used fractional amplitude of low-frequency fluctuation (fALFF) technology to investigate spontaneous cerebral activity in patients with monocular blindness (MB) and in healthy controls (HCs).
MATERIAL AND METHODS: Thirty MB patient and 15 HCs were included in this study. All subjects were scanned by resting-state functional magnetic resonance imaging (rs-fMRI). The independent sample t test and chi-squared test were applied to analyze demographics of MB patients and HCs. The 2-sample t test and receiver operating characteristic (ROC) curves were applied to identify the difference in average fALFF values between MB patients and HCs. Pearson’s correlation analysis was applied to explore the relationship between the average fALFF values of brain areas and clinical behavior in the MB group.
RESULTS: MB patients had lower fALFF values in the left anterior cingulate and higher fALFF values in the left precuneus and right and left inferior parietal lobes than in HCs. Moreover, the mean fALFF values of MB patients in the left anterior cingulate had negative correlations with the anxiety scale score (r=-0.825, P<0.001) and the depression scale score (r=-0.871, P<0.001).
CONCLUSIONS: Our study found that MB patients had abnormal spontaneous activities in the visual and vision-related regions. The finding of abnormal neuronal activity helps to reveal the underlying neuropathologic mechanisms of vision loss.

Keywords: Anxiety, Blindness, Depression, Magnetic Resonance Imaging