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Echo-Tracking Technique in Ultrasonography Can Monitor Changes in Carotid Artery Elastic Function at Early Stage of Intensity-Modulated Radiation Therapy for Nasopharyngeal Carcinoma

Wei Han, Junjie Liu, Zhijie Liu, Xiaodong Zhu

Department of Radiotherapy, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland)

Med Sci Monit 2020; 26:e926260

DOI: 10.12659/MSM.926260

Available online: 2020-09-03

Published: 2020-09-09


BACKGROUND: We used echo-tracking (ET) technique to observe short-term dynamic changes of the carotid artery in nasopharyngeal carcinoma (NPC) patients after intensity-modulated radiation therapy (IMRT).
MATERIAL AND METHODS: Sixty-one NPC patients received IMRT. In the irradiation group, the carotid artery was examined by ultrasonography before radiotherapy, at 2, 4, and 6 weeks after the start of radiotherapy, and at 3 and 6 months after the end of radiotherapy. In the control group, the carotid artery was examined by ultrasonography before radiotherapy of patients in the irradiation group, and at 3 and 6 months after the end of radiotherapy of patients in the irradiation group.
RESULTS: During radiotherapy for the 61 patients, the maximum dose on the carotid artery was 65.14±4.35 Gy, the average dose was 57.46±4.12 Gy, and the 50% volume dose was 51.80±5.32 Gy. At the end of irradiation, Ep (kPa) and ß values were significantly different from those before treatment.
CONCLUSIONS: The present study demonstrates that the elastic function of the carotid artery can be significantly affected when the irradiation dose exceeds 45 Gy.

Keywords: Carotid Arteries, Cranial Irradiation, Nasopharyngeal Neoplasms



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