01 January 1998
Role of neutrophil in chronic allergic inflammation of nasal mucosa with polyps
Elżbieta Tryka, Daniel ChibowskiMed Sci Monit 1998; 4(6): BR922-928 :: ID: 451724
Abstract
We examined the contribution of neutrophil in chronic rhinitis with polyps, especially in allergic rhinitis. The investigation was conducted on 21 patients. Twelve had allergic rhinitis, five Ñ infectious rhinitis and four Ñ aspirin intolerance. We identified neutrophil elastase and eosinophil major basic protein (MBP) in polyp tissue using immunoenzymatic method. We determined the coexistence of degranulated neutrophils and eosinophils and the damaged epithelium.
Results: In the group with allergic rhinitis 5 subjects had rich infiltrations of neutrophils with an extracellular elastase deposition and the damaged epithelium in the immediate area. Degranulated eosinophils were not found at those areas.
Conclusion: We can conclude that both eosinophils and neutrophils are present in the nasal mucosa of patients with allergic rhinitis. They have an ability to release the contents of their granules in complex pathophysiological processes, which cause substantial lesion of the epithelium. The neutrophil can play an important role in some kinds of allergic rhinitis. This role has not yet been fully recognized and require further research.
Keywords: allergic rhinitis, nonallergic rhinitis, Neutrophils, Eosinophils
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
26 Feb 2024 : Clinical Research
Predictive Value of Combined HbA1c and Neutrophil-to-Lymphocyte Ratio for Diabetic Peripheral Neuropathy in...Med Sci Monit In Press; DOI: 10.12659/MSM.942509
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952