20 May 2010
Usefulness of perfusion-weighted MR imaging in the differential diagnosis of Alzheimer’s disease and mild cognitive impairment
Anna Zimny, Paweł Szewczyk, Anna Czarnecka, Elżbieta Trypka, Renata Wojtyńska, Jerzy Leszek, Marek SąsiadekMed Sci Monit 2010; 16(1): 5-10 :: ID: 880575
Abstract
Background: Accurate diagnosis of Alzheimer’s disease (AD) and mild cognitive impairment (MCI) is still a clinical problem. The aim of the study was to evaluate the usefulness of perfusion-weighted magnetic resonance (MR) imaging (PWI) and analysis of disturbances in the cerebral microcirculation in the differential diagnosis of AD and MCI.
Material/Methods: Thirty-four patients with AD (mean age, 71.6 years; Mini-Mental State Examination [MMSE] 18), 23 with MCI (mean age, 66.2 years; MMSE, 27), and 15 normal control subjects (mean age, 69 years; MMSE, 29.5) were enrolled in the study. All subjects underwent psychiatric examination and psychological tests. PWI was performed on a 1.5-T MR unit using dynamic susceptibility contrast (DSC) method (IV contrast, 0.3 mM/kg, 5 mL/s). Cerebral blood volume (CBV) measurements relative to cerebellum (rCBV) were assessed in both hippocampi, and temporoparietal and frontal association cortices as well as in the posterior cingulate region.
Results: Significantly lower rCBV values (P<.05) were found in temporoparietal, left frontal, and posterior cingulate cortices in AD patients compared with normal control subjects and in temporoparietal cortices and posterior cingulate region compared with MCI patients. In MCI patients, significantly lower rCBV values were noticed in the left frontal and posterior cingulate cortices compared with normal control subjects.
Conclusions: Our results confirm an important role of cerebral hypoperfusion, particularly in the posterior cingulate region, in the pathogenesis of AD and MCI. Assessment of rCBV, especially in the posterior cingulate cortex, can be useful in the differential diagnosis of AD and MCI.
Keywords: cerebral perfusion, magnetic resonance, Alzheimer’s Disease, Dementia
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952