01 November 1999
Age-related changes of total and free testosterone levels among Polish adult males
Marek Mędraś, Elżbieta Rogucka, Ewa JankowskaMed Sci Monit 1999; 5(6): CR1158-1162 :: ID: 503169
Abstract
The aim of this study was to evaluate the age changes of both total and free testosterone levels in 186 adult, healthy and occupationally active Polish men, aged between 22 and 67. Free and total testosterone levels were measured by means of standard immunoassay kits. Since the distribution of hormonal parameters differed from normal, non-parametric statistical analyses (Spearman coefficient) were used. Free testosterone levels reached peak values in the 30-34 year age category (21.1 pg/ml), while a decline of total testosterone began in 22-24 yr old males (6.15 ng/ml). Afterwards, they both began to decrease gradually with age. Free and total testosterone levels strongly correlate with age (respectively r=-0.478; p=0.000 for free testosterone and r=-0.251; p=0.0005 for total testosterone). Initial values (maximal age levels) of total testosterone were reduced by 45%, while that of free testosterone by 40% in men aged 55 and older. Free testosterone concentrations demonstrated a relatively regular decrease during the investigated period, whereas a progressive decline of total testosterone levels was disturbed about the age of 45 yrs by an unexpected rapid increase of its concentrations to values of 5.7 ng/ml, similar to those observed in men, aged between 25 and 29. An endocrinological interpretation of this phenomenon remains unclear. Our study confirmed the marginal importance of total testosterone levels in comparison with free testosterone concentrations in the diagnostics of andropausal hypogonadism.
Keywords: male aging, free and total testosterone levels, andropause
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952