20 May 2010
Lateral rectus muscle as a new reference point in estimation of Graves’ ophthalmopathy activity
Agata Majos, Michał Pająk, Marcin Elgalal, Marek Olszycki, Ludomir StefańczykMed Sci Monit 2010; 16(1): 80-85 :: ID: 880588
Abstract
Background: The clinical progression of Grave’s ophthalmopathy (GO) is evaluated based on different parameters. Still, there is greater opportunity to carry out morphometric measurements, than to perform a quasi patho-physiological assessment.
The aims of this study were to evaluate the correlation of T2 relaxation time to muscle volume based on MR imaging and to investigate whether individual physical relativization of extraocular muscle volume significantly influences results.
Material/Methods: Ten controls and 20 patients underwent MR examination. Quantitative muscle assessment was carried out using a numerical segmentation image technique. T2 relaxation times were measured for each muscle, and a standardization algorithm was applied based on T2 relaxation time of ipsilateral frontal lobe white matter.
For each extraocular muscle, an absolute volume and a relative value were calculated by subtracting from each of these muscles’s volume from the volume of the lateral rectus muscle (RM) within the same orbital cavity.
Results: Highest correlation for relative T2 relaxation time and muscle volume was observed for inferior RM (value of r=0.520, which increased to r=0.660 after relativization). An increase in correlation for medial RM was also noted from r=0.473 to r=0.48. However, this correlation decreased slightly for superior RM from a value of r=0.597 to r=0.525.
Conclusions: Oculomotor muscle volume closely correlates to T2 relaxation time. Individual physical objectification significantly increases this correlation for MRM and IRM and consequently enables more precise use of muscle volume as an indicator of GO. Relativization is essential for data from both magnetic resonance and computer tomography studies.
Keywords: Graves’ ophthalmopathy, volume assessment, computer applications
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952