Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review

Alexander Weymann; Anton Sabashnikov; Sadeq Ali-Hasan-Al-Saegh; Aron-Frederik Popov; Seyed Jalil Mirhosseini; William L. Baker; Mohammadreza Lotfaliani; Tong Liu; Hamidreza Dehghan; Senol Yavuz; Michel Pompeu Barros de Oliveira Sá; Jae-Sik Jang; Mohamed Zeriouh; Lei Meng; Fabrizio D’Ascenzo; Abhishek J. Deshmukh; Guiseppe Biondi-Zoccai; Pascal M. Dohmen; Hugh Calkins; Integrated Meta-Analysis of Cardiac Cardiac Surgery and Cardiology-Group IMCSC-Group]

doi:10.12659/MSMBR.902558

31 March 2017 : Meta-Analysis

Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review

Alexander Weymann^{ABCDEFG 1*}, Anton Sabashnikov^{ABCDEFG 2,3}, Sadeq Ali-Hasan-Al-Saegh^{ABCDEFG 4}, Aron-Frederik Popov^{ABCDEFG 5}, Seyed Jalil Mirhosseini^{ABCDEFG 4}, William L. Baker^{ABCDEFG 6}, Mohammadreza Lotfaliani^{ABCDEFG 4}, Tong Liu^{ABCDEFG 7}, Hamidreza Dehghan^{ABCDEFG 8}, Senol Yavuz^{ABCDEFG 9}, Michel Pompeu Barros de Oliveira Sá^{ABCDEFG 10,11,12}, Jae-Sik Jang^{ABCDEFG 13}, Mohamed Zeriouh^{ABCDEFG 2,3}, Lei Meng^{ABCDEFG 14}, Fabrizio D’Ascenzo^{ABCDEFG 15}, Abhishek J. Deshmukh^{ABCDEFG 16}, Guiseppe Biondi-Zoccai^{ABCDEFG 17,18}, Pascal M. Dohmen^{ABCDEFG 1}, Hugh Calkins^{ABCDEFG 19}, Integrated Meta-Analysis of Cardiac Cardiac Surgery and Cardiology-Group IMCSC-Group]

DOI: 10.12659/MSMBR.902558

Med Sci Monit Basic Res 2017; 23:97-140

Authors information Article notes Copyright and License information

¹Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
²Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, Harefield Hospital, Harefield Middlesex, United Kingdom
³Department of Cardiothoracic Surgery, University Hospital Cologne, Cologne, Germany
⁴Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
⁵Department of Cardiac Surgery, University Hospital Frankfurt am Main, Frankfurt am Main, Germany
⁶ University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, USA
⁷Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, 2nd Hospital of Tianjin Medical University, Tianjin, China
⁸Department of Health Technology Assessment, Shahid Sadoughi University of Medical Sciences and Health Services, Yazd, Iran
⁹Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey
¹⁰Division of Cardiovascular Surgery, Pronto Socorro Cardiológico de Pernambuco – PROCAPE, Recife, Brazil
¹¹ Nucleus of Postgraduate and Research in Health Sciences of Faculty of Medical Sciences and Biological Sciences Institute (FCM/ICB), Recife, Brazil
¹² University of Pernambuco – UPE, Recife, Brazil
¹³Department of Cardiology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea
¹⁴Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy
¹⁵Mayo Clinic Heart Rhythm Section, Cardiovascular Diseases, Mayo Clinic, Rochester, USA
¹⁶Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy
¹⁷Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy
¹⁸Department of Cardiology, Johns Hopkins Medical Institutions, Baltimore, USA

^*Corresponding Author: Alexander Weymann, e-mail: [email protected]

^AStudy design/planning
^BData collection/entry
^CData analysis/statistics
^DData interpretation
^EPreparation of manuscript
^FLiterature analysis/search
^GFunds collection

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Supplementary Table 1 Included, and excluded studies.

Clinical outcomes and biomarkers	Studies were identified and screened [n]	Studies were excluded according to title, abstract or full text [n]	Studies were included [n]
Fibrinogen	315	275	40 approved articles with totally 58 enrolled data for meta-analysis
D-dimer	238	121	30 approved articles with totally 40 enrolled data for meta-analysis
PF1–2	86	79	7 approved articles with totally 9 enrolled data for meta-analysis
AT-III	98	94	4 approved articles with totally 6 enrolled data for meta-analysis
TAT	127	120	7 approved articles with totally 8 enrolled data for meta-analysis
t-PA	437	426	11 approved articles with totally 14 enrolled data for meta-analysis
PAI	91	80	11 approved articles with totally 15 enrolled data for meta-analysis
Alpha-2 antiplasmin	18	18	–
Fibrinopeptide-A	21	18	3 approved articles with totally 4 enrolled data for meta-analysis
u-PA	29	29	–
Plasmin-antiplasmin	22	21	1 approved articles with
vWF	185		21 approved articles with totally 32 enrolled data for meta-analysis
sTM	37	31	6 approved articles with totally 7 enrolled data for meta-analysis

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Predictive Role of Coagulation, Fibrinolytic, and Endothelial Markers in Patients with Atrial Fibrillation, Stroke, and Thromboembolism: A Meta-Analysis, Meta-Regression, and Systematic Review

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