Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

Alexander Weymann; Sadeq Ali-Hasan-Al-Saegh; Anton Sabashnikov; Aron-Frederik Popov; Seyed Jalil Mirhosseini; Tong Liu; Mohammadreza Lotfaliani; Michel Pompeu Barros de Oliveira Sá; William L. L. Baker; Senol Yavuz; Mohamed Zeriouh; Jae-Sik Jang; Hamidreza Dehghan; Lei Meng; Luca Testa; Fabrizio D'Ascenzo; Umberto Benedetto; Gary Tse; Luis Nombela-Franco; Pascal M. Dohmen; Abhishek J. Deshmukh; Cecilia Linde; Giuseppe Biondi-Zoccai; Gregg W. Stone; Hugh Calkins; Integrated Meta-Analysis of Cardiac Surgery and Cardiology-Group [IMCSC-Group]

doi:10.12659/MSMBR.903320

12 May 2017 : Meta-Analysis

Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

Alexander Weymann^{DE 1*}, Sadeq Ali-Hasan-Al-Saegh^{BCDE 2}, Anton Sabashnikov^{DE 3,4}, Aron-Frederik Popov^{E 3,5}, Seyed Jalil Mirhosseini^{AD 6}, Tong Liu^{F 7}, Mohammadreza Lotfaliani^{F 6}, Michel Pompeu Barros de Oliveira Sá^{D 8,9}, William L. L. Baker^{B 10}, Senol Yavuz^{B 11}, Mohamed Zeriouh^{B 3,4}, Jae-Sik Jang^{B 12}, Hamidreza Dehghan^{C 13}, Lei Meng^{A 7}, Luca Testa^{D 14}, Fabrizio D'Ascenzo^{EF 15}, Umberto Benedetto^{AC 16}, Gary Tse^{CD 17}, Luis Nombela-Franco^{CF 18}, Pascal M. Dohmen^{EG 1,19}, Abhishek J. Deshmukh^{AF 20}, Cecilia Linde^{E 21}, Giuseppe Biondi-Zoccai^{AC 22,23}, Gregg W. Stone^{DE 24}, Hugh Calkins^{ADE 25}, Integrated Meta-Analysis of Cardiac Surgery and Cardiology-Group [IMCSC-Group]

DOI: 10.12659/MSMBR.903320

Med Sci Monit Basic Res 2017; 23:179-222

Authors information Article notes Copyright and License information

¹Department of Cardiac Surgery, University Hospital Oldenburg, European Medical School Oldenburg-Groningen, Carl von Ossietzky University Oldenburg, Oldenburg, Germany
²Afshar Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
³Department of Cardiothoracic Transplantation and Mechanical Circulatory Support, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom
⁴Department of Cardiothoracic Surgery, University Hospital of Cologne, Cologne, Germany
⁵Department of Thoracic and Cardiovascular Surgery, University Hospital Goethe University Frankfurt, Frankfurt, Germany
⁶Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Isfahan, Iran
⁷Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, China
⁸Division of Cardiovascular Surgery, Pronto Socorro Cardiológico de Pernambuco – PROCAPE, Recife, Brazil
⁹ University of Pernambuco – UPE, Recife, Brazil
¹⁰Department of Pharmacy, University of Connecticut/Hartford Hospital Evidence-Based Practice Center, Hartford, USA
¹¹Department of Cardiovascular Surgery, Bursa Yuksek Ihtisas Training and Research Hospital, Yıldırım/Bursa, Turkey
¹²Department of Cardiology, Busan Paik Hospital, Inje University College of Medicine, Jin-gu, South Korea
¹³Department of Health Technology Assessment, Shahid Sadoughi University of Medical Sciences and Health Services, Isfahan, Iran
¹⁴Department of Cardiology, IRCCS Pol. S. Donato, San Donato Milanese, Italy
¹⁵Division of Cardiology, Department of Medical Sciences, Città della Salute e della Scienza Hospital, University of Turin, Turin, Italy
¹⁶Bristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, United Kingdom
¹⁷Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong
¹⁸ Instituto Cardiovascular, Hospital Universitario Clínico San Carlos, Madrid, Spain
¹⁹Department of Cardiothoracic Surgery, Faculty of Health Science, University of the Free State, Bloemfontein, South Africa
²⁰Mayo Clinic Heart Rhythm Section, Cardiovascular Diseases, Mayo Clinic, Rochester, USA
²¹Department of Cardiology, Karolinska University Hospital, Karolinska Institut, Solna, Sweden
²²Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy
²³Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy
²⁴New York Presbyterian Hospital, Columbia University Medical Center, New York, USA
²⁵Department of Cardiology, Johns Hopkins Medical Institutions, Baltimore, USA

^*Corresponding Author: Alexander Weymann, e-mail: [email protected]
^*Corresponding Author: Seyed Jalil Mirhosseini, e-mail: [email protected]

^AStudy design/planning
^BData collection/entry
^CData analysis/statistics
^DData interpretation
^EPreparation of manuscript
^FLiterature analysis/search
^GFunds collection

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Supplementary Table 2 Extra details of characteristics of each study for exploration of heterogeneity factors.

First Author	Geographic Area	Total N	Total age	Total male	Total DM	Total HTN	Total CS	Total Diuretic	Total ACEI	Total. Statin	Total BB	AC-code	Chronic or not

Balci (Male subjects) []⁸	European	35	ND	100	ND	ND	ND	ND	ND	ND	ND	5	ND
Balci (Female subjects) []⁸	European	153	ND	0	ND	ND	ND	ND	ND	ND	ND	5	ND
Gurses []⁹	European	172	56.5	52.35	13.95	51.75	ND	ND	ND	ND	ND	5	Non-chronic
Karatas []¹⁰	European	621	61.05	72.5	23	45.5	64	ND	ND	0	ND	2	Non-chronic
Korantzopoulos []¹¹	European	101	76.5	46.5	27.5	88.5	ND	ND	ND	ND	ND	3	Non-chronic
Akdag []¹²	European	148	64.05	60	16.5	22	23.5	ND	ND	ND	ND	6	Combined types
Akyuz []¹³	European	90	62.25	72.25	29	42.5	34.25	14.5	20.75	32.5	23	4	Combined types
Chavaria []¹⁴	North America	290	65.65	74.5	29.05	65.65	55.05	ND	ND	ND	ND	5	ND
Drabik (Persistent AF) []¹⁵	European	97	60.1	64.975	20	48.85	22.85	ND	52.25	53.15	60.6	4	Non-chronic
Drabik (Paroxysmal AF) []¹⁵	European	91	60	55.15	16.4	46.05	20	ND	54.05	47.45	57.25	4	Non-chronic
Acet (Paroxysmal AF) []¹⁶	European	134	62.05	44	16.5	18	21.5	ND	ND	ND	ND	5	Non-chronic
Acet (Persistent and permanent AF) []¹⁶	European	126	62.85	43.5	21.5	24	28.5	ND	ND	ND	ND	5	Combined types
Arik (effective INR) []¹⁷	European	248	69.65	40.7	6.05	68.95	13.7	27	59.25	ND	59.7	5	chronic
Arik (ineffective INR) []¹⁷	European	248	69.45	37.9	6.85	65.35	12.1	24.2	55.65	ND	61.3	5	chronic
Distelmaier []¹⁸	North America	198	73.5	61	24	60.5	ND	ND	ND	ND	ND	5	Non-chronic
Erdogan (with normal ventricular rate) []¹⁹	European	67	69.55	49.28	10	65	6	17	53.5	10	43.3	3	chronic
Erdogan (with high ventricular rate) []¹⁹	European	63	68.8	49.055	13.3	56.5	8	25	52	3.5	43.3	3	chronic
Zheng []²⁰	Asian	217	61.735	58.63	10.84	49.275	32.74	ND	ND	ND	ND	5	ND
Xu (without thrombotic events) []²¹	Asian	115	66.095	50.45	37.4	53.1	38.25	ND	42.6	29.55	43.55	4	chronic
Xu (with thrombotic events) []²¹	Asian	115	67.975	51.3	36.5	57.5	31.25	ND	40.8	26.05	40.95	4	chronic
Gungor []²²	European	177	47.2	57.8	3.35	14.75	23.15	ND	ND	ND	10.6	3	ND
Liu []²³	Asian	234	ND	ND	ND	ND	ND	ND	ND	ND	ND	5	Non-chronic
Sarikaya []²⁴	European	126	71.03	50	38	100	ND	ND	ND	ND	ND	5	ND
Sonmez []²⁵	European	85	70	37	24.21	63.255	ND	14.16	47.17	15.41	35.6	4	Non-chronic
Ulu []²⁶	European	57	ND	ND	0	0	ND	ND	ND	ND	ND	5	ND
Berge []²⁷	European	189	75	71.025	8	48	ND	19	21	34.5	28	4	Combined types
Ertas (without stroke) []²⁸	European	111	53.5	51	8.5	32.5	2	ND	17	ND	30	3	ND
Ertas (with stroke) []²⁸	European	63	54.5	47	10	47	5	ND	24	ND	16.5	3	ND
Gungor []²⁹	European	140	42.55	66.4	0	0	31	ND	ND	ND	ND	5	ND
Turgut []³⁰	European	162	63	52	100	65.5	41.5	6.5	23.5	18	16.5	4	chronic
Jaremo (healthy control) []³¹	European	82	67.5	66.73	5.17	21.55	2.585	18.9	13.79	14.655	41.3	4	ND
Jaremo (disease control) []³¹	European	130	71.5	68.1	12.75	43.75	9.485	28.65	26.25	25.05	55.92	4	ND
Sahin []³²	European	144	64.865	49.75	100	66.5	44.5	ND	ND	ND	ND	5	Non-chronic
Tekin []³³	European	219	73.5	35.5	13.5	68.5	19	ND	ND	ND	ND	5	chronic
Turfan (without stroke) []³⁴	European	135	59.5	54.55	15.6	33.1	55.5	ND	ND	ND	ND	4	ND
Turfan (with stroke) []³⁴	European	121	62.5	52.05	24.6	27	50.6	ND	ND	ND	ND	4	ND
Feng []³⁵	Asian	374	65.8	61.75	17.65	53.2	25.65	23	41.95	44.85	42.5	4	ND
Liu (Paroxysmal AF) []³⁶	Asian	101	64.35	62.5	5	32.5	ND	ND	21	15	34	3	Non-chronic
Liu (Persistent AF) []³⁶	Asian	107	65.8	61	6.5	35	ND	ND	29	13.5	35	3	Non-chronic
Yoshizaki []³⁷	Asian	176	70	76	32	65	52.5	ND	37.55	38.85	10.6	5	Non-chronic
Hayashi (Paroxysmal AF) []³⁸	Asian	27	57.95	92.5	14.5	48.5	ND	ND	40.5	26	ND	2	Non-chronic
Hayashi (Chronic AF) []³⁸	Asian	27	61.45	92.5	11.05	52	ND	ND	37	26	ND	2	chronic
Fu []³⁹	Asian	169	54.45	63.5	ND	ND	42.45	ND	ND	12.9	6.1	4	Combined types
Liu []⁴⁰	Asian	451	58.35	51.435	ND	100	23.7	14.85	71.55	61.15	42.7	5	Combined types
Letsas (Paroxysmal AF) []⁴¹	European	93	64.35	59	6	60.5	ND	ND	43	15.5	34	5	Non-chronic
Letsas (Permanent AF) []⁴¹	European	89	66.6	59.5	11	63	ND	ND	52.5	13.5	35.5	5	chronic
Luan (Persistent AF) []⁴²	Asian	53	53.25	50.855	0	26.21	30.2	ND	ND	ND	ND	5	Non-chronic
Luan (Paroxysmal AF) []⁴²	Asian	55	50.99	52.385	0	24.93	30.9	ND	ND	ND	ND	5	Non-chronic
Alberti []⁴³	European	51	64.45	47.05	ND	ND	ND	ND	ND	ND	ND	1	Non-chronic
Dai []⁴⁴	Asian	522	53.065	74.7	6.1	17	ND	ND	ND	ND	ND	5	Non-chronic
Ichiki []⁴⁵	Asian	72	51.5	80.205	16	37.5	ND	ND	8	15	ND	5	Non-chronic
Yao (Persistent AF) []⁴⁶	Asian	150	54.1	76.8	7.4	0	42.4	ND	ND	8.1	13.2	4	Non-chronic
Yao (Paroxysmal AF) []⁴⁶	Asian	339	53.35	74.95	4.25	0	46.55	ND	ND	6.6	7.85	4	Non-chronic
Colkesen []⁴⁷	European	190	54	38	18.5	41.5	ND	ND	ND	28	ND	4	Non-chronic
Choudhury (disease control) []⁴⁸	European	192	63.31	74	10.5	66.4	ND	33.15	55.7	46.5	43.7	4	ND
Choudhury (healthy control) []⁴⁸	European	177	62.305	72	4.1	31.8	ND	17.75	26.85	14.45	21.9	4	ND
Pirat []⁴⁹	European	39	49.5	51.5	8	26.5	32	ND	24.5	ND	38	5	Non-chronic
Yip []⁵⁰	Asian	82	65.75	63.05	9.7	34.7	5.65	ND	23.4	15.3	ND	3	chronic
Kamath (Paroxysmal and persistent AF) []⁵¹	European	62	63.5	51.6	ND	ND	ND	ND	ND	ND	ND	1	Non-chronic
Kamath (Permanent AF) []⁵¹	European	124	66	52.65	ND	ND	ND	ND	ND	ND	ND	1	chronic
Kamath (Paroxysmal AF) []⁵²	European	58	63	48.27	6.85	24.135	5.17	ND	ND	ND	ND	4	Non-chronic
Kamath (Permanent AF) []⁵²	European	116	65	52.29	5.15	30.45	5.17	ND	ND	ND	ND	4	chronic
Kamath []⁵³	European	143	70	54.18	5.375	29.565	ND	ND	ND	ND	ND	1	ND
Kamath []⁵⁴	European	57	ND	ND	ND	ND	ND	ND	ND	ND	ND	1	chronic
Peverill []⁵⁵	Oceania	163	55	84.6	ND	ND	ND	ND	ND	ND	ND	5	ND
Kahn (without stroke) []⁵⁶	North America	81	ND	ND	ND	ND	ND	ND	ND	ND	ND	1	chronic
Kahn (with stroke) []⁵⁶	North America	36	ND	ND	ND	ND	ND	ND	ND	ND	ND	1	chronic
Lip []⁵⁷	European	77	ND	ND	ND	ND	ND	ND	ND	ND	ND	1	chronic
Gustafsson (without stroke) []⁵⁸	European	40	77	ND	10	25	25	ND	ND	ND	ND	1	ND
Gustafsson (with stroke) []⁵⁸	European	40	77	ND	12.5	27.5	30	ND	ND	ND	ND	1	ND

Gurses []⁹	European	86	56.8	57.7	15.8	48.55	ND	ND	21.2	16.5	ND	5	Non-chronic
Hongliang Li []⁵⁹	Asian	104	62.5	43.9	24.45	46.1	37.45	ND	41	49.65	42.4	4	Non-chronic
Yanagisawa (without heart failure) []⁶⁰	Asian	678	61.1	76	12.5	46	ND	3.5	35	ND	31.5	5	Non-chronic
Yanagisawa (with heart failure) []⁶⁰	Asian	79	63.6	74.5	20	38	ND	77.5	58	ND	81.5	5	Non-chronic
Aksu []⁶¹	European	49	59.65	52.5	16.5	48.5	47	ND	ND	ND	ND	5	Non-chronic
Gurses []⁶²	European	299	55.7	51.15	13.2	42.4	31	ND	ND	ND	ND	4	Non-chronic
Karavelioglu []⁶³	European	218	64.4	41.095	18	58.5	21	ND	23.5	10.5	67	5	Non-chronic
Wen []⁶⁴	Asian	75	63.62	ND	7.5	57.5	20	ND	ND	30	ND	5	Non-chronic
Guo Xueyuan []⁶⁵	Asian	379	49.665	73.55	0	0	ND	ND	ND	ND	ND	5	ND
Aribas []⁶⁶	European	149	60	ND	29	62.5	18.5	ND	ND	ND	ND	2	Non-chronic
Bing Li []⁶⁷	Asian	288	57	71.1	28.65	55.05	38.15	ND	38	14.2	27.7	5	Non-chronic
Canpolat []⁶⁸	European	251	55.2	54.85	15.15	44.35	36.55	ND	51.25	18.05	ND	5	Non-chronic
Im []⁶⁹	Asian	499	56.4	73.65	15.55	43.9	ND	ND	ND	ND	ND	5	Non-chronic
Xiao-nan HE []⁷⁰	Asian	330	59.5	66.3	ND	48.65	ND	ND	50	14	52	5	Non-chronic
Ferro []⁷¹	European	144	70.95	56.5	14	87.5	5	ND	46.5	22.5	ND	2	Non-chronic
Smit []⁷²	European	100	64	73.8	11.9	65.95	15	41.2	69.05	36.65	89.3	5	Non-chronic
Wang (Paroxysmal AF) []⁷³	Asian	103	57.5	34.8	ND	41.65	ND	ND	ND	ND	4.24	5	Non-chronic
Wang (Persistent AF) []⁷³	Asian	55	52.5	74.65	ND	50.35	ND	ND	ND	ND	5.65	5	Non-chronic
Liu (Paroxysmal AF) []⁷⁴	Asian	77	56	75.6	ND	37.3	ND	ND	ND	ND	ND	2	Non-chronic
Liu (Persistent AF) []⁷⁴	Asian	44	53.05	84.85	ND	51.2	ND	ND	ND	ND	ND	2	Non-chronic
Vizzardi []⁷⁵	European	106	69	61	12.05	ND	ND	ND	8	ND	ND	5	Non-chronic
Letsas []⁷⁶	European	72	54.55	81.5	21.5	21.5	ND	ND	23	14.5	ND	5	Non-chronic
Korantzopoulos []⁷⁷	European	30	68.5	48.39	7.1	64.25	4.75	30.95	35.7	5.55	ND	5	Non-chronic

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Prediction of New-Onset and Recurrent Atrial Fibrillation by Complete Blood Count Tests: A Comprehensive Systematic Review with Meta-Analysis

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