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04 August 2020: Database Analysis

Sirtuin 3 mRNA Expression is Downregulated in the Brain Tissues of Alzheimer’s Disease Patients: A Bioinformatic and Data Mining Approach

Shuang Song 12ABCDEF , Bin Li 12A , Zhen Jia 12C , Li Guo 12AG*

DOI: 10.12659/MSM.923547

Med Sci Monit 2020; 26:e923547

Table 2 Summary of the GEO2R analysis of the sirtuin mRNA levels between the Alzheimer’s disease and control groups in 8 datasets.

Gene symbolNumber of downregulated datasetsNumber of upregulated datasetsTotal number of datasetsAdjusted P valueP valuetBLog2FCDatasets with most significant adjusted P value (GEO ID)
SIRT10882.29E-253.43E-2611.2648.518.83E-02GSE33000
SIRT21683.85E-064.19E-075.245.942.74E-01GSE132903
SIRT37088.49E-309.62E-31−12.4058.90−8.21E-02GSE33000
SIRT40376.53E-171.53E-189.5931.441.37E-01GSE44768
SIRT57082.26E-438.33E-45−15.6791.06−1.42E-01GSE33000
SIRT62281.39E-051.98E-064.834.382.07E-01GSE15222
SIRT70683.95E-246.38E-2510.9345.629.93E-02GSE33000

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416