27 July 2020: Laboratory Research
Biochemical Feature of LMO2 Interactome and LMO2 Function Prospect
Wenhao Wang 1BC* , Yaxin Chen 1BC* , Ying Chang 2AD* , Wei Sun 1EFG*DOI: 10.12659/MSMBR.924421
Med Sci Monit Basic Res 2020; 26:e924421
Supplementary Table 2 Information of subcellular distribution and functional categories of core LMO2 interaction partners.
| Subcellular/functional category | Genes |
|---|---|
| Transcriptional factors | COMMD8, ZBED5, NR2C1, DCAF6, POLR2C, RBPJ |
| Epigenetic regulators | MLL5, ASH2L, SAP18, PRMT2, GLYATL1, BBS2 |
| DNA recombination and repair | SWI5, POLI, RBPJ, VWA3B, ZMAT1 |
| RNA splicing, processing and transport | TOE1, MTREX, SF3B1, IFIH1, EIF4A3, RPP40, RBM4, RAE1, RTCB |
| Others | BOC, CCDC173, CCDC127, C1orf194, MORN2, PARD3B, STAG3, CFOP1, UBE2Q1, |
| Metabolism & redox | , , , DAO, PRMT2, GLYATL1, MMADHC, ADA, GLS, PCCA, DPYS, TALDO1, GSTA4, ADH1, , |
| Cell signalling regulators | PDE11A, WDR91, LITAF, , ZNF622, , , , NR2C1, |
| Cytoskeleton & introcellular traffic | RAE1, TTC8, DOCK11, , SH3YL1, ABI1, NCKAP1, DCTN6, CAPRIN2, SEC23B, STX8, AP3S1, RINT2, MORN2, BBS2 |
| Ubiquitination related factors | UBE2Q1, DCAF6, WSB1, FAM188A, POMP |
| RNA related and Ribosomal member | RTCB, BTG3, NARS, QARS, GSPT2, RBM4, RPL30, IFIH1, EIF4A3 |
| Others | POLR2C, COMMD8, ANKRD7, SEC31A |
| Inner membrane_respiratory chain | ,, UQCRFS1, SQOR, , , PARL |
| Matrix_metabolism | ALDH2, PCCA, MMADHC, GLS, LDHB, NADK2 |
| Ribosome/tRNA related | MTIF2, MRPL24, MRPL48, MRPL45, , QARS |
| Others | CAPRIN2, HEBP2, RACK1, LACTB |
| Plasma membrane | BOC, OSMR, , GJC1, LITAF, CAPRIN2, BBS2, MLL5, ABI1, SH3YL1, STX8, STAG3, ADA, ADH1B |
| ER | SEC31A, SEC23B, DAD1, PLOD1, RINT1, ABI1, STX8, RTCB, GJC1, CCDC80, |
| Golgi apparatus | LUM, OGN, MGAT5, AP3S1, SEC23B, LITAF, STX8, ZNF622 |
| Lysosome/endosome | LUM, OGN, WDR91, LITAF, STX8, HEBP2, ADA |
| Peroxisome | DAO |
| Extracellular | |
| Matrix and matrix-related enzymes | LUM, OGN, MFAP5, APOH, CCDC80, MGAT5, CPA3, DAD1, PLOD1 |
| Secretory ligands | RLN1, C1S, CCL4 |
| Others | |