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20 January 2021: Meta-Analysis

Association Between Mitochondrial DNA Copy Number and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Dose-Response Meta-Analysis

Zhu Zhu 1ABCDEF , Yixiu Liu 2B , Didi Wu 1C , Hongpeng Wang 2ABCDEF*

DOI: 10.12659/MSM.928327

Med Sci Monit 2021; 27:e928327

Table 1 The baseline characteristics of included studies.

AuthorYearCancer typeRegionStudy DesignSamplesMethod for mtDNA
Kim2004Head and neck squamous cell carcinomaAmericaCase-controlSalivaqRT-PCR
Jiang2005Head and neck squamous cell carcinomaAmericaCase-controlSalivaqRT-PCR
Mondal2013Oral squamous cell carcinomaIndiaCase-controlTissuesqRT-PCR
Cheau-Feng Lin2014Oral/oropharyngeal/hypopharyngeal/nasopharyngeal/laryngeal/nasal cancerTaiwan, ChinaRetrospective cohortPBLqRT-PCR
Dang2014Laryngeal cancerXi’an, ChinaCohortTissuesqRT-PCR
Ghosh2014Nasopharyngeal carcinomaIndiaCase-controlPBLqRT-PCR
He2014Oral premalignant lesionsAmericaCase-controlPBLqRT-PCR
Wang2018Oral cavity/Oropharynx/Larynx/nasal sinuses/parotid/salivary glandNanjing, ChinaCase-controlPBLqRT-PCR
Kim14/6550.0773 (0.0307, 0.2693)* 0.0257 (0.0134, 0.0584)* Cox Iβ-actin4
Jiang94/6560.076** 0.054** Cox Iβ-actin6
0.055** 0.046** Cox IIβ-actin
Mondal124/1400.22* 0.89* D-loopGAPDH6
Cheau-Feng Lin75/808.22 (4.41, 17.55)* 4.84* tRNA-leu18s6
Dang204/4011.91±4.35** 4.72±0.70** MT-ND1β-actin6
Ghosh64/1001.98* 4.11* D-loopGAPDH6
He143/3571.36±0.74** 1.11±0.32** MT-ND1HGB7
Wang570/5974.33 (1.38, 29.85)* 3.5 (1.93, 11.22)* MT-ND1HGB8
* Median (first quartile, third quartile) mtDNA copy number level;
** mean±sd mtDNA copy number level. N – number; NOS – Newcastle-Ottawa Quality Assessment Scale; PBL – peripheral blood lymphocytes; qRT-PCR – real-time quantitative PCR; Cox – cytochrome c oxidase.

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416