Logo Medical Science Monitor Basic Research

Call: 1.631.470.9640
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research Logo Medical Science Monitor Basic Research

20 January 2021: Meta-Analysis

Association Between Mitochondrial DNA Copy Number and Head and Neck Squamous Cell Carcinoma: A Systematic Review and Dose-Response Meta-Analysis

Zhu Zhu 1ABCDEF , Yixiu Liu 2B , Didi Wu 1C , Hongpeng Wang 2ABCDEF*

DOI: 10.12659/MSM.928327

Med Sci Monit 2021; 27:e928327

Table 2 Subgroup analyses for the two class meta-analysis.

StudiesN. of StudiesSMD (95% CI)Heterogeneity (I2; P value)N. of studiesOR (95% CI)Heterogeneity (I2; P value)
All studies90.71 (0.28–1.15)96.8%;40.87 (0.52–1.44)82.5%; 0.001
Study design
 Cohort21.18 (−0.02,2.38)95.8%;
 Case-control70.58 (0.11,1.04)96.8%;40.87 (0.52–1.44)82.5%; 0.001
Sample
 PBL40.33 (0.06–0.60)83.7%;31.03 (0.61–1.73)79.9%; 0.007
 Tissues20.76 (−1.27,2.79)98.8%;10.52 (0.30–0.87)
 Saliva31.33 (−0.06,2.72)98.6%;
Region
 China30.91 (0.16–1.66)95.9%;11.06 (0.84–1.34)
 India2−0.26 (−0.45 – −0.07)0%; 0.88420.51 (0.34–0.77)0%; 0.938
 America41.10 (0.23,1.97)98.0%;11.69 (1.14–2.51)
mtDNA gene
 ND130.88 (0.30–1.46)95.9%;21.30 (0.83–2.05)74.9%; 0.046
 D-loop2−0.26 (−0.45 – −0.07)0%; 0.88420.51 (0.34–0.77)0%; 0.938
 Cox I/Cox II31.33 (−0.06–2.72)98.6%;
 tRNA-leu10.57 (0.25–0.90)
NOS score
13.79 (3.22–4.35)
 660.35 (−0.13–0.84)94.9%;20.51 (0.34–0.77)0%; 0.938
 >620.44 (0.33–0.54)2.4%; 0.31121.30 (0.83–2.05)74.9%; 0.046
N – number; SMD – standardized mean differences; OR – odds ratio; CI – confidence interval; PBL – peripheral blood lymphocytes; Cox – cytochrome c oxidase; NOS – Newcastle-Ottawa Quality Assessment Scale.

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416