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16 August 2021: Meta-Analysis

Prognostic Significance of Microvascular Invasion in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-Analysis

Huangbao Li 1ACEF , Weiwei Pan 2AEF , Liu Xu 1BE , Dong Yin 3CDE , Shuqun Cheng 34AEFG* , Fengqing Zhao 1AEF*

DOI: 10.12659/MSM.930545

Med Sci Monit 2021; 27:e930545

Table 2 Definition of MVI in PDAC in different studies.

StudyDescriptionOriginDefinition methodologyDefinition
Yamada et al []9 Microscopic venous invasionBloodElastica-Masson staining1
Wang et al []14 Microvascular invasionBloodImmunohistochemical, CD34 as a marker of vascular endothelial cell1
Panaro et al []10 Microvascular invasionBloodNA1
Naito et al []32 Lymphovascular invasion and microvessel invasionLymph and bloodD2-40 for LVI, Elastica-van Giesson for MVI2
Epstein et al []17 Lymphovascular invasionBlood or lymphHematoxylin and eosin, vascular or lymphatic vessels were not distinguished3
Chatterjee et al []30 Lymphovascular invasionBlood or lymphHematoxylin and eosin, lymphovascular was distinguished by micro-muscular vessels invaded (MVI) or not (LVI)4
1. A cluster of intravascular cancer cells surrounded by an elastic layer; 2. Tumor cell invasion into lymph ducts comprised of D2-40 positive endothelial cells was categorized as LVI. Tumor cell invasion findings in veins with elastic fiber measuring more than half the diameter on Elastica-van Giesson staining or Victoria blue hematoxylin and eosin staining were categorized as MVI; 3. Spreading of cancer cells into microscopic vascular or lymphatic vessels; 4. Tumor invasion into lymphovascular spaces lined by endothelium without muscle layer (LVI) and tumor invasion into micro-muscular vessels (MVI). LVI – lymphovascular invasion; MVI – microvascular invasion.

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416