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24 May 2021: Meta-Analysis

Relationship of Programmed Death-1 (PD-1) and Programmed Death Ligand-1 (PD-L1) Polymorphisms with Overall Cancer Susceptibility: An Updated Meta-Analysis of 28 Studies with 60 612 Subjects

Wenjing Zhang 12BCDEF , Yuxuan Song 34ABEF* , Xiangcheng Zhang 1ACEG*

DOI: 10.12659/MSM.932146

Med Sci Monit 2021; 27:e932146

Table 1 Characteristics of the selected articles.

GenotypenFirst authorYearCountryEthnicityCancer typeCaseControlHWEGenotype methods
PD-1 rs102045256Zhou R-M2016ChinaAsianEsophageal cancer33226325512382960.748PCR–LDR
Zang B2019ChinaAsianEsophageal cancer63329420503595510.388qRT-PCR
Ren H-T2016ChinaAsianBreast cancer54248257512402910.879PCR
Tang WF2015ChinaAsianGastric cancer21123169532193090.119PCR–LDR
Qiu H2014ChinaAsianEsophageal cancer43240317632433450.038PCR–LDR
Tang WF2017ChinaAsianEsophageal cancer544397988706721320.887PCR–LDR
PD-1 rs115688215Fathi F2019IranAsianBasal cell cancer3183247582550.099PCR-RFLP
Bayram S2012TurkeyAsianHepatocellular cancer0191450561800.038PCR-RFLP
Haghshenas MR2011IranAsianBreast cancer8365634552310.725PCR-RFLP
Ma Y2015ChinaAsianNon-small cell lung cancer042610221424560.009PCR-RFLP
Fathi F2018IranAsianCarcinomas of head and neck4119275321130.162PCR-RFLP
PD-L1 rs177188833Xie Q2018ChinaAsianHepatocellular carcinoma2158210869230.025PCR-RFLP
Li Q2016ChinaAsianGastric cancer871317748160.054PCR
Chen S2017ChinaAsianHepatocellular carcinoma122107748160.054PCR
PD-1 rs222798111Fathi F2019IranAsianBasal cell carcinoma308793150134360.466PCR-RFLP
Zhou R-M2016ChinaAsianEsophageal cancer52241291462293100.683PCR–LDR
Li XF2016ChinaAsianCervical cancer441674587101620.004PCR-RFLP
Ma Y2015ChinaAsianNon-small cell lung cancer68216244982462560.004PCR-RFLP
Fathi F2018IranAsianCarcinomas of head and neck1669651371660.317PCR-RFLP
Hua Z2011ChinaAsianBreast cancer22169295242102440.012PCR-RFLP
Mojtahedi Z2012IranAsianColorectal cancer32109593689750.290PCR-RFLP
Li Y2016ChinaAsianOvarian cancer351233351512503190.837PCR–LDR
We L2017ChinaAsianOvarian cancer74267644600.571RT-PCR
Haghshenas MR2010IranAsianBreast cancer50191194461451370.445PCR-RFLP
Sanaz Savabkar2013IranAsianGastric cancer66650770890.136PCR-RFLP
PD-1 rs222798210Zhou R-M2016ChinaAsianesophageal cancer1493051301502971380.702PCR-LDR
Tan D2017ChinaAsianovarian cancer87601711148110.075qRT-PCR
Ma Y2015ChinaAsiannon-small cell lung cancer34314837404168280.056PCR-RFLP
Hua Z2011ChinaAsianbreast cancer111249127952681430.121PCR-RFLP
Kasamatsu T2019JapanAsianmultiple myeloma55116404355260.285PCR-RFLP
Tang WF2015ChinaAsiangastric cancer75168871632921480.448PCR-LDR
Qiu H2014ChinaAsianesophageal cancer1593031541893251670.245PCR-LDR
Tang WF2017ChinaAsianesophageal cancer2205492724168164420.309PCR-LDR
Tang WF2017ChinaAsianesophageal cancer87168751482921630.448PCR-LDR
Ren H-T2016ChinaAsianbreast Cancer1722571281372991460.503PCR
PD-L1 rs28906586Chen Y-B2014ChinaAsiannon-small cell lung cancer2424832662610.671PCR-RFLP
Xie Q2018ChinaAsianhepatocellular carcinoma1704961395560.844PCR-RFLP
Zhou R-M2017chinaAsianesophageal cancer18161396151444180.541PCR-LDR
Li Q2016chinaAsiangastric cancer79202983940.959PCR
Ma Y2015ChinaAsiannon-small cell lung cancer41610665128440.785PCR-RFLP
Chen S2017chinaAsianhepatocellular carcinoma95271983940.959PCR
PD-1 rs3608432310Zhou R-M2016ChinaAsianesophageal cancer1343031471422981450.649PCR-LDR
Zang B2019ChinaAsianesophageal cancer8132673121887610.919qRT-PCR
Hua Z2011ChinaAsianbreast cancer1162711031122601400.673PCR
Kasamatsu T2019JapanAsianmultiple myeloma50110513354370.154PCR-RFLP
Bôas Gomez GV2018BrazilCaucasianCutaneous Melanoma6182260252250.405qRT-PCR
Ma Y2015ChinaAsiannon-small cell lung cancer1382461441482961560.747PCR-RFLP
Li Y2016ChinaAsianovarian cancer1693011501293231680.251PCR-LDR
We L2017chinaAsianovarian cancer3757222153360.849PCR-LDR
Zhao Y2018ChinaAsiancolorectal cancer116207961232531210.686PCR-RFLP
Tang WF2017ChinaAsianesophageal cancer282521238444800430PCR-LDR
PD-L1 rs41438156Wang W2013ChinaAsianGastric cancer457288135188700.746PCR
Tan D2017ChinaAsianOvarian cancer3182515478380.334qRT-PCR
Xie Q2018ChinaAsianHepatocellular carcinoma501017465104310.316PCR-RFLP
Zhou R-M2017ChinaAsianEsophageal cancer21127787203289850.275PCR-LDR
Li Q2016ChinaAsianGastric cancer4147134976160.09PCR
Chen S2017ChinaAsianHepatocellular carcinoma5050234976160.09PCR
PD-1 rs74218618Tang WF2017ChinaAsianEsophageal cancer791226221684080.368PCR-LDR
Zang B2019ChinaAsianEsophageal cancer343370100457411920.977PCR-RFLP
Hua Z2011ChinaAsianBreast cancer11146333121303700.884PCR-RFLP
Tang WF2015ChinaAsianGastric cancer791226221684080.367PCR-LDR
Qiu H2014ChinaAsianEsophageal cancer21168411251884600.295PCR-LDR
Jie Ge2015ChinaAsianColorectal cancer14187395171634400.684PCR-RFLP
Tang WF2017ChinaAsianEsophageal cancer413586425445411660.232PCR-LDR
Ren H-T2016ChinaAsianBreast cancer23196341282053470.746PCR

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416