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15 January 2022: Database Analysis

Prediction of Patient Survival with Psoas Muscle Density Following Transjugular Intrahepatic Portosystemic Shunts: A Retrospective Cohort Study

Biyu Zhang ABCDEF , Weimin Cai ABCDEF , Feng Gao BE , Xinran Lin BC , Ting Qian F , Kaier Gu B , Bingxin Song B , Tanzhou Chen A*

DOI: 10.12659/MSM.934057

Med Sci Monit 2022; 28:e934057

Table 1 Characteristics of the study population, stratified by survival event.a

VariablesAll patients n=273Nonsurvivor n=31Survivor n=242P valueb
Basic information
Age, y53.54±10.5157.55±9.6353.02±10.530.024
BMI22.67 (20.51–25.01)22.76 (20.49–25.17)22.19 (20.69–23.82)0.590
Sex
 Male194221720.990
 Female79970
Diabetes6912570.068
Hypertension273240.932
Smoking10511940.717
Splenectomy221210.294
Etiology of cirrhosis0.115
 Alcoholic53647
 Viral (HBV or HCV)15114137
 Both alcohol and viral35332
Othersc 34826
Reasons for TIPS0.563
 EGVB24626220
 RF13310
 Portal vein thrombosis716
 Othersd 716
TIPS targeted puncture0.007
 Left branch of the intrahepatic portal vein19920179
 Right branch of the intrahepatic portal vein61655
 Otherse 1358
Laboratory parameters
 RBC, ×102.93 (2.47–3.44)2.91 (2.53–3.46)2.93 (2.47–3.44)0.788
 WBC, ×103.79 (2.51–36.33)3.60 (2.90–4.86)3.85 (2.45–6.54)0.695
Lymphocyte, ×100.76 (0.51–1.19)0.72 (0.50–0.97)0.77 (0.52–1.25)0.461
 Neutrophil, ×102.42 (1.51–4.30)2.46 (1.54–3.60)2.42 (1.49–4.33)0.659
 Platelet, ×1064.0 (45.5–92.5)56.0 (42.0–85.0)64.5 (46.5–93.3)0.415
 Hemoglobin, g/L83.0 (69.0–97.0)86.0 (75.0–101.0)82.5 (69.0–96.0)0.306
 Albumin, g/L30.18±5.3928.34±4.1030.41±5.490.015
 Total bilirubin, μmol/L20.0 (13.5–29.5)20.0 (13.5–29.5)19.0 (13.0–28.0)0.003
 ALT, U/L24.0 (17.0–36.0)39.0 (20.0–52.0)23.0 (17.0–34.0)0.007
 AST, U/L35.0 (26.5–52.0)50.0 (33.0–86.0)35.0 (25.0–48.0)0.001
 Serum creatinine, μmol/L64.0 (52.0–75.0)63.0 (50.0–79.0)64.0 (53.0–75.0)0.698
 Serum sodium, mmol/L138.0 (135.0–141.0)138.0 (134.0–140.0)138.0 (136.0–141.0)0.383
 Prothrombin time, s16.9 (15.6–18.5)17.2 (16.0–19.4)16.9 (15.6–18.4)0.146
 PMD, HU51.7 (46.4–55.1)47.5 (43.4–50.4)52.2 (47.1–55.4)
 INR1.40 (1.26–1.58)1.39 (1.24–1.60)1.41 (1.27–1.58)0.402
Clinical scores
 Child-Pugh score7 (6–9)8 (7–9)7 (6–9)0.090
 MELD score11.45 (9.72–13.63)12.02 (10.67–14.39)11.29 (9.57–13.58)0.081
 MELD-Na score10.92 (7.47–14.50)12.92 (9.13–15.33)12.92 (9.13–15.33)0.147
ALT – alanine aminotransferase; AST – aspartate aminotransferase; BMI – body mass index; EGVB – esophageal gastric-fundus variceal bleeding; HBV – hepatitis B virus; HCV – hepatitis C virus; HU – Hounsfield units; INR – international standardization ratio; MELD – model for end-stage liver disease; MELD-Na – composite index of model for end-stage liver disease and serum sodium; PMD – psoas muscle density; RBC – red blood cell count; RF – refractory ascites; TIPS – transjugular intrahepatic portosystemic shunt; WBC – white blood cell count.
a Data were tested for normality. Descriptive statistics are expressed as numbers or mean values (±SD), as appropriate. Continuous variables are expressed as means±SD or medians with interquartile ranges.
b The test or the Mann-Whitney U test was used to compare 2 groups, and χ test or Fisher exact test was used to compare categorical variables.
c Others included primary biliary cirrhosis, autoimmune diseases, Budd-Chiari syndrome, and cryptogenic cirrhosis.
d Others included preventive therapy, portal system thrombosis, and alleviation of abdominal discomfort.
e Others included portal vein trunk, right branches of the portal vein, and confluence of the left branches of the portal vein.

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416