20 May 2010
1H-MRS in mild cognitive impairment (MCI) – the role of particular metabolites in prediction of MCI conversion to AD
Jerzy Walecki, Agnieszka Pawłowska, Tomasz Gabryelewicz, Jarosław B. Ćwikła, Maria Barcikowska, Tomasz NesterukMed Sci Monit 2010; 16(1): 11-18 :: ID: 880576
Abstract
Background: This study evaluated predictive value of brain 1H MRS in patients with MCI, who could have converted to Alzheimer disease (AS).
Material/Methods: The examination was performed on a group of 31 MCI subjects. All underwent neurologic and psychiatric tests, routine laboratory investigations, and standard neuropsychological examinations. MCI diagnosis was established based on criteria of the Mayo Clinic Group. ¹H MRS was performed with a single-voxel method using PRESS sequence. The VOI was located in the frontal, medial, and external temporal lobe regions.
Results: Patients had annual clinical control at least twice; in the beginning, 9 subjects were diagnosed as an amnestic MCI, and the others (22) had multidomain MCI. Baseline metabolic ratios (1H MRS) between 3 groups of patients, indicated significant difference in left frontal lobe in mI/H20 ratio, between patients with SD (0.27) and DP (0.22) (P=.03). There was a significant difference NAA/Cr (1.77 vs 1.43; P=.02). Significant differences within left temporal external lobes were found between patients with SD and DP in NAA/H2O ratio (0.55 vs 51; P=.04). Additional differences within medial temporal lobe were found between patients with DP and AD in Glx/H2O ratio (0.44 vs 0.34) on the right side (P=.02).
Conclusions: 1H MRS seems to be a sensitive method providing biochemical information using in vivo approach in patients with initial MCI, who, in significant numbers, developed a disease and/or converted to AD. Our findings concerning 1H MRS patients with MCI require further prospective studies.
Keywords: MCI, mild cognitive impairment, AD, Alzheimer’s disease • ¹H MRS, proton magnetic resonance spectroscopy
Editorial
01 March 2024 : Editorial
Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-ThalassemiaDOI: 10.12659/MSM.944204
Med Sci Monit 2024; 30:e944204
In Press
18 Mar 2024 : Clinical Research
Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative StudyMed Sci Monit In Press; DOI: 10.12659/MSM.944136
21 Feb 2024 : Clinical Research
Potential Value of HSP90α in Prognosis of Triple-Negative Breast CancerMed Sci Monit In Press; DOI: 10.12659/MSM.943049
22 Feb 2024 : Review article
Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...Med Sci Monit In Press; DOI: 10.12659/MSM.943168
23 Feb 2024 : Clinical Research
A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...Med Sci Monit In Press; DOI: 10.12659/MSM.943732
Most Viewed Current Articles
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952