01 July 2008
Sex difference in the association of the angiotensin converting enzyme I/D polymorphism and body mass index
Michael J WackerABCDEFG, Michael P GodardACDEFG, Everlee H McCabeBC, Joseph E DonnellyA, John K KellyCDEFMed Sci Monit 2008; 14(7): CR353-357 :: ID: 863663
Abstract
Background
Angiotensin converting enzyme (ACE) catayzes the formation of angiotensin I to angiotensin II. A polymorphism has been identified in intron 16 in which a 287 base-pair alu sequence was found to be present (insertion or I) or absent (deletion or D) in the population. ACE and the components of the renin-angiotensin system are expressed in adipose tissue and therefore the I/D polymorphism within ACE may be associated with obesity.
Material and Method
This study involved genotyping two groups with differing body mass indexes (BMI
Results
The male groups differed significantly in allele frequency at the ACE locus with the I allele more frequent in the BMI >or=30 group (p<0.05). While the female BMI >or=30 group also had a higher I allele frequency than the BMI
Our results demonstrate a sex difference in the association of the I/D polymorphism and BMI. Our findings differ from some other previous studies using various population groups which indicate that the ACE I/D polymorphism may be differentially associated with obesity depending on multiple factors.
Keywords: Peptidyl-Dipeptidase A - genetics, Obesity - physiopathology, Mutation - genetics, Genetic Predisposition to Disease, Gene Frequency, Sex Characteristics, Polymorphism, Genetic, Body Mass Index
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