18 February 2014 : Letter/Correspondence
Letter to the Editor regarding: Epistatic effects in pathophysiology of asthma and the “missing heritability” of this disease
Andrzej BrodziakADEF, Piotr Z. BrewczyńskiADFGDOI: 10.12659/MSM.890506
Med Sci Monit 2014; 20:274-275
Abstract
The authors of the letter try to assess the importance of Yoshikawa's paper presenting so-called epistatic effects and analyses as a tool useful for explanation of the genetic conditioning of asthma. They note that the investigations of the genetic determinants of other chronic diseases such as atherosclerosis, coronary artery disease and Parkinson's disease also encountered epistatic effects. The authors of the letter state that, in fact, the epistatic analyses it is one of possible endeavors, which try to explain so called "missing heritability". They enumerate other recognized mechanisms, which are proposed that explain the missing heritability. The authors of the letter appreciate the conclusions of Yoskikawa's team important for clinicians. They emphasize that really asthma is a clinical condition that is diagnosed or suspected in course of occurrence of symptoms, which not allow unequivocally to diagnose this disease. In such circumstances the precise recognition of the specific genetic profile of a patient (his status of expression of genes recognized as pathogenic, as well as the epistatic interactions) will improve the possibilities of treatment and prevention. The authors of the letter postulate however, that this practical diagnostic approach must be continually modified in course of the future trials of explanations of reasons of the discussed "missing heritability".
Keywords: Epistasis, Genetic - genetics, Asthma - physiopathology, Models, Biological, Phenotype, Receptors, Immunologic - genetics, Signal Transduction - immunology
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