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03 November 2014 : Case report  Japan

Increases in Serum CYFRA21-1 Concentration during Successful Treatment with Crizotinib

Unusual clinical course, Unusual or unexpected effect of treatment, Unexpected drug reaction

Nobuhiro KanajiABEF, Akira TadokoroE, Naoki WatanabeE, Takuya InoueE, Tomoya IshiiE, Hiroaki DobashiE, Shuji BandohAE

DOI: 10.12659/AJCR.891194

Am J Case Rep 2014; 15:480-484

Abstract

BACKGROUND: Increases in tumor marker concentrations usually suggest disease progression.

CASE REPORT: We here describe on 3 patients with non-small cell lung cancer whose serum concentrations of CYFRA21-1 increased in spite of successful treatment with crizotinib. Discontinuation of crizotinib resulted in a rapid decrease in serum CYFRA21-1 concentrations in all cases. In 1 patient with progressive disease, in spite of increasing the dose of crizotinib, CYFRA21-1 concentrations decreased.

CONCLUSIONS: Crizotinib can induce increases in CYFRA21-1 concentration without disease progression. Pulmonologists and oncologists should be aware of this novel phenomenon, and focus on interpretation of CYFRA21-1 concentrations in monitoring tumor response to crizotinib treatment.

Keywords: Carcinoma, Non-Small-Cell Lung - drug therapy, Antigens, Neoplasm - blood, Follow-Up Studies, Keratin-19 - blood, Lung Neoplasms - drug therapy, Protein Kinase Inhibitors - therapeutic use, Pyrazoles - therapeutic use, Pyridines - therapeutic use, Tomography, X-Ray Computed, Tumor Markers, Biological - blood

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923