23 July 2016 : Review article
Cardiac Hypertrophy: An Introduction to Molecular and Cellular Basis
Mostafa SamakABCDEF, Javid FatullayevABCDEF, Anton SabashnikovABCDEF, Mohamed ZeriouhABCDEF, Bastian SchmackABCDEF, Mina FaragBCDE, Aron-Frederik PopovBCDE, Pascal M. DohmenBCDEG, Yeong-Hoon ChoiABCDEF, Thorsten WahlersABCDEF, Alexander WeymannABCDEFGDOI: 10.12659/MSMBR.900437
Med Sci Monit Basic Res 2016; 22:75-79
Abstract
Ventricular hypertrophy is an ominous escalation of hemodynamically stressful conditions such as hypertension and valve disease. The pathophysiology of hypertrophy is complex and multifactorial, as it touches on several cellular and molecular systems. Understanding the molecular background of cardiac hypertrophy is essential in order to protect the myocardium from pathological remodeling, or slow down the destined progression to heart failure and cardiomyopathy. In this review we highlight the most important molecular aspects of cardiac hypertrophic growth in light of the currently available published research data.
Keywords: Adaptor Proteins, Signal Transducing, Cardiomyopathy, Hypertrophic, Cell Adhesion Molecules
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