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Fibromyalgia and its New Lessons for Neuropsychiatry

Laura Duque, Gregory Fricchione

(Department of Psychiatry, Massachusetts General Hospital – Harvard Medical School, Boston, MA, USA)

Med Sci Monit Basic Res 2019; 25:169-178

DOI: 10.12659/MSMBR.915962

ABSTRACT: Fibromyalgia (FM) is a centralized pain state that until recently has been shrouded in mystery and questionable as a disease entity in the eyes of many physicians, who considered it purely psychogenic. Fibromyalgia is now thought of as a discrete diagnosis with a clustering of symptoms characterized by central nervous system pain amplification along with anergia, memory loss, disturbances of mood, and sleep disruption. The condition is present in approximately 2% to 8% of the population.
We review the link between inflammatory mechanisms and FM from a neuropsychiatric perspective.
Recent studies are pointing to a neuroinflammatory etiology that may open up more effective treatment strategies in the future.
Better conceptualization of FM may also elucidate a neuropsychiatric understanding of how nociception, dysthymia, and suicidality co-develop and feed off one another.

Keywords: Central Nervous System, Fibromyalgia, Neuropsychiatry, Neuroimmunomodulation

This paper has been published under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially.
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